Results 141 to 150 of about 7,237,339 (340)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Technical Notes on the Near Surface Experiments of Submerged Submarine

International Journal of Maritime Technology, 2016
In this study, the experimental analysis on the bare hull resistance coefficient of submarine at snorkel depth is represented. The experiments are conducted in marine laboratory of Admiral Makarov University.
Mohammad Moonesun, Firouz Ghasemzadeh, Yuri Korol, Valeri Nikrasov, Alexi Yastreba, Alexander Ursolov, Asghar Mahdian   +6 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Numerical and Experimental Investigation of Dam-Break Wave on a Single Building Situated Downstream [PDF]

, 2013
Dam-break flow may cause severe damages on land and population locateddownstream due to flush flooding. In addition to the complexity inherent in dam break flow,existence of buildings changes the rapidly varying flow pattern downstream making theproblem ...
Hasan Guzel, Selahattin Kocaman
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Experimental and Numerical Study on the Hydrodynamic Efficiency of Permeable Caissons Barriers

Journal of Eta Maritime Science
Breakwaters are constructed to protect beaches and ports from high storms and waves. By bringing calm to the port, breakwaters also increase ship safety and operation. This paper presents a study of the breakwater partially submerged in water, consisting
Karim Badr Hussein, Mohamed Ibrahim, Samah H. Abd El Ghany   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparativa de tres modelos CFD en la hidrodinámica de captaciones de fondo con tamices Coanda

Ingeniería del Agua
Este trabajo evalúa la capacidad de tres modelos de dinámica de fluidos computacional (computational fluid dynamics, CFD) para resolver el flujo sobre un tamiz Coanda de captación de fondo con agua clara.
José María Carrillo Sánchez, Juan Tomás García Bermejo, Luis Gerardo Castillo Elsitdié   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Three-Dimensionally Printed Metal-Coated Flow-Field Plate for Lightweight Polymer Electrolyte Membrane Fuel Cells

Energies
This study investigates the potential for affordable and lightweight polymer electrolyte membrane fuel cells (PEMFCs) using lightweight flow-field plates, also referred to as bipolar plates.
Dasol Kim, Geonhwi Kim, Juho Na, Hyeok Kim, Jaeyeon Kim, Guyoung Cho, Taehyun Park   +6 more
doaj   +1 more source