Results 61 to 70 of about 221,463 (266)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A melt flow index-based approach for the viscosity curves determination

Materials Research Proceedings
Abstract. To optimize the polymers processing technologies, a rheological characterization of the polymer is essential to predict its behavior at specific temperatures and under varying shear rates. Simulating this process requires providing the simulation software with viscosity curves for the polymer to be processed, ensuring a reliable simulation ...
OUBELLAOUCH Keltoum, PELACCIA Riccardo, POZZI Paolo, ZANIBONI Giulia, ORAZI Leonardo, DONATI Lorenzo, REGGIANI Barbara   +6 more
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Analytical method for determining the saturation point of superplasticizers in cement pastes using the Marsh cone

Cerâmica
The optimum dosage of superplasticizer (SP) additives is determined by the saturation point of SP (SPS), obtained on cement paste by the utilization of the Marsh cone. Obtaining the SPS is important because it defines the amount of SP that should be used
O. F. da Silva, P. C. C. Gomes, K. A. M. Morais   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

FIA-FAAS method for tannin determination based on a precipitation reaction with hemoglobin

Journal of the Brazilian Chemical Society, 2003
A flow system, coupled with flame atomic absorption spectrometry (FIA-FAAS), was developed for tannin determination in pigeon pea samples, exploring the precipitation reaction between tannins and proteins. Sample extracts obtained by sonication with a 50%
Ferreira Edilene C., Souza Gilberto B., Nogueira Ana Rita A.   +2 more
doaj  

Determinação turbidimétrica em fluxo de cloridrato de fluoxetina em formulações farmacêuticas Flow-injection turbidimetric determination of fluoxetine hydrochloride in pharmaceutical formulations

Química Nova, 2009
A simple, accurate and precise flow-injection turbidimetric procedure for the determination of fluoxetine hydrochloride in pharmaceutical formulations is reported.
Willian Toito Suarez, Elen Romão Sartori, Érica Ferreira Batista, Orlando Fatibello-Filho   +3 more
doaj   +1 more source

DETERMINATION OF THE PLASTICITY INDEX USING SLOPE OF FALL CONE FLOW CURVE

, 2023
This paper presents two simple equations that can be used to compute the plasticity index of soil using the correlation between the slope of the British fall cone flow curve and the plasticity index. The models were developed using British fall cone test results using soils of widely varying plasticity, including commercial bentonite.
openaire   +1 more source