Results 61 to 70 of about 221,223 (264)

KAJIAN OPTIMASI SKEMA PEMBANGKIT LISTRIK TENAGA MIKRO HYDRO RANTAU SULI di KABUPATEN MERANGIN, PROVINSI JAMBI

Jurnal Teknik Pengairan, 2018
Dengan semakin menurunnya ketersediaan bahan bakar fosil maka perlu adanya energi alternatif pengganti yang baru dan terbarukan (Anonim, 2013).Pembangkit listrik tenaga air adalah salah satu alternatif energi yang relatif lebih stabil untuk memenuhi akan
Adhe Indra Nurprayogo, Widandi Soetopo, Emma Yuliani   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Potential Legacy of SWOT Mission for the Estimation of Flow–Duration Curves

Remote Sensing
Flow–duration curves (FDCs) provide a compact view of the historical variability of river flows, reflecting climate conditions and the main hydrologic features of river basins.
Alessio Domeneghetti, Serena Ceola, Alessio Pugliese, Simone Persiano, Irene Palazzoli, Attilio Castellarin, Alberto Marinelli, Armando Brath   +7 more
doaj   +1 more source

Evaluation of seasonal catchment dynamic storage components using an analytical streamflow duration curve model

Sustainable Environment Research, 2022
Dynamic storage refers to groundwater storage that is sensitive to rainfall infiltration, streamflow generation, evapotranspiration, and other variables involving groundwater gain or loss. It plays a crucial role in habitat maintenance and the mitigation
Chia-Chi Huang, Hsin-Fu Yeh
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Assessing the effects of four SUDS scenarios on combined sewer overflows in Oslo, Norway: evaluating the low-impact development module of the Mike Urban model

Hydrology Research, 2020
Paved surfaces, increased precipitation intensities in addition to limited capacity in the sewer systems, cause a higher risk of combined sewer overflows (CSOs).
Ragni R. Hernes, Ashenafi S. Gragne, Elhadi M. H. Abdalla, Bent C. Braskerud, Knut Alfredsen, Tone M. Muthanna   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

IDENTIFICATION AND DELINEATION OF HYDROLOGICAL HOMOGENEOUS REGIONS BY USING L-MOMENT FOR SELECTED BASINS

Journal of Engineering and Sustainable Development, 2016
The paper presents results of an application of the L-moments based regional flood frequency analysis to annual maximum peak (AMP) flows observed at five stations (Balikian,Jundian.Manguba,Bekhme and Eski-Kelek) located on the main stream of the Greater
عبدالوهاب محمد يونس
doaj