Results 51 to 60 of about 3,714,854 (310)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Design and performance of compliant grinding tools for blade root smooth grinding

Jin'gangshi yu moliao moju gongcheng
ObjectivesThe difficulty in machining complex structural components such as aircraft engine blade roots is a common problem in the precision machining industry, and the stability of grinding tool performance is crucial for achieving automated machining ...
Mingcong LI, Peisen TIAN, Yun HUANG, Shengbo YAN, Lai ZOU, Wenxi WANG   +5 more
doaj   +1 more source

The resistance and flow field characteristics of moonpool and its improvement forms

Zhongguo Jianchuan Yanjiu, 2020
[Objectives] The moonpool is a type of opening structure through the hull from deck to bottom, but it often brings adverse impacts on the performance of resistance due to its complex flow.[Methods] The computational fluid dynamics(CFD) method was ...
ZHAN Xingyu, MAO Xiaofei
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effect of Vaneless Diffuser Shape on Performance of Centrifugal Compressor

Applied Sciences, 2020
The influence of four different vaneless diffuser shapes on the performance of centrifugal compressors is numerically studied in this paper. One of the studied shapes was a parallel wall diffuser. Two others had the width reduced only from hub and shroud
Qian Zhang, Qiuhong Huo, Lei Zhang, Lei Song, Jianmeng Yang   +4 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Microstructure and Mechanical Properties of Cu-CoatedCarbon-Nanotubes-Reinforced Aluminum Matrix Composites Fabricated by Ultrasonic-Assisted Casting

Metals
Carbon nanotubes (CNTs) are considered ideal nanoscale reinforcement for the development of high-performance metal matrix composites due to their unique structure and excellent mechanical properties.
Xiaojian Dong, Min Zeng, Hong Yan
doaj   +1 more source

Using 3D Stringy Gravity to Understand the Thurston Conjecture

, 2003
We present a string inspired 3D Euclidean field theory as the starting point for a modified Ricci flow analysis of the Thurston conjecture. In addition to the metric, the theory contains a dilaton, an antisymmetric tensor field and a Maxwell-Chern Simons
Alvarez E, Bona C, Braham S P, Chow B, Chow B, De Francia M, Dowker S, Eisenhart L P, Eisenhart L P, G Kunstatter, Gegenberg J, Hamilton R S, Hamilton R S, Hawking S W, Isenberg J, J Gegenberg, Kaloper N, Kodama H, Koike T, Perelman G, Piotrkowska K, Poincaré H, Polyakov A M, Scott P, Thurston W P, Wald R M, Weeks J R, Yano K, Yasuno K   +28 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source