Results 91 to 100 of about 16,608,295 (250)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Dendritic structure and receptive-field organization of optic flow processing interneurons in the fly [PDF]

, 1998
Krapp HG, Hengstenberg B, Hengstenberg R. Dendritic structure and receptive-field organization of optic flow processing interneurons in the fly. Journal of neurophysiology.
Hengstenberg, Roland, Holger G. Krapp, Hengstenberg, B., Hengstenberg, R., Krapp, Holger G., Roland Hengstenberg, Krapp, H., Bärbel Hengstenberg, Hengstenberg, Bärbel   +8 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Advection-dispersion in symmetric field-flow fractionation channels [PDF]

, 1998
We model the evolution of the concentration field of macromolecules in a symmetric field-flow fractionation (FFF) channel by a one-dimensional advection-diffusion equation. The coefficients are precisely determined from the fluid dynamics.
Roberts, A. J., Suslov, Sergey A.
core  

Integrated radial basis function methods for structural, fluid flow and fluid-structure interaction analyses [PDF]

, 2012
The present research is concerned with the development of new numerical methods based on integrated radial basis function network (IRBFN) and collocation techniques for solving structural, fluid-flow and fluid-structure-interaction problems.
Ngo-Cong, Duc
core   +1 more source

Numerical Analysis of Flow Field Distribution and Flow Resistance of Open-Cell Foam Structures

Taiyuan Ligong Daxue xuebao
Purposes This research is carried out in order to systematically study the flow characteristics, heat and mass transfer characteristics of air flow field of open-cell metal foam.
ZHENG Zijun, WANG Genwei, SONG Hui, HAN Pengfei   +3 more
doaj   +1 more source

Fluid–structure interaction study of three-dimensional vehicle model under crosswind

Advances in Mechanical Engineering, 2015
It is very important to study fluid–structure interaction of vehicles which move in strong crosswind environment. For solving a fluid–structure interaction problem, the effect of the deformation and vibration of the elastic body on the flow field should ...
Hui Zhu, Yang Zhigang
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source