Results 31 to 40 of about 2,109,023 (306)

The Scavenging Effect of Myoglobin from Meat Extracts toward Peroxynitrite Studied with a Flow Injection System Based on Electrochemical Reduction over a Screen-Printed Carbon Electrode Modified with Cobalt Phthalocyanine: Quantification and Kinetics

Biosensors, 2021
The scavenging activity of myoglobin toward peroxynitrite (PON) was studied in meat extracts, using a new developed electrochemical method (based on cobalt phthalocyanine-modified screen-printed carbon electrode, SPCE/CoPc) and calculating kinetic ...
Ioana Silvia Hosu, Diana Constantinescu-Aruxandei, Florin Oancea, Mihaela Doni   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linear stability analysis of (Cu-Al2O3)/water hybrid nanofluid flow in porous media in presence of hydromagnetic, small suction and injection effects

, 2020
In this paper, a stability analysis of a hybrid nanofluid flow between two parallel and stationnary plates filled with a porous medium was investigated. The hybrid nanofluid is composed of water as regular fluid, copper ( Cu ) and alumina ( Al 2 O 3 ) as
P. T. Kapen, Cédric Gervais Njingang Ketchate, D. Fokwa, G. Tchuen   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Automated Systems with Fluorescence Detection for Metal Determination: A Review

Molecules
Industrialization has led to environmental pollution with various hazardous chemicals including pollution with metals. In this regard, the development of highly efficient analytical methods for their determination has received considerable attention to ...
Arina Skok, Natalia Manousi, Aristidis Anthemidis, Yaroslav Bazel   +3 more
doaj   +1 more source

The lipidome of an omnivorous insect responds to diet composition and social environment

Ecology and Evolution, 2022
Lipids are biomolecules with essential roles in metabolic processes, signaling, and cellular architecture. In this study, we investigated changes in the lipidome of the house cricket Acheta domesticus subjected to diets of different nutritional ...
Yeisson Gutiérrez, Marion Fresch, Christoph Scherber, Jens Brockmeyer   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Determinação turbidimétrica em fluxo de cloridrato de fluoxetina em formulações farmacêuticas Flow-injection turbidimetric determination of fluoxetine hydrochloride in pharmaceutical formulations

Química Nova, 2009
A simple, accurate and precise flow-injection turbidimetric procedure for the determination of fluoxetine hydrochloride in pharmaceutical formulations is reported.
Willian Toito Suarez, Elen Romão Sartori, Érica Ferreira Batista, Orlando Fatibello-Filho   +3 more
doaj   +1 more source

Dynamic Flow Approaches for Automated Radiochemical Analysis in Environmental, Nuclear and Medical Applications

Molecules, 2020
Automated sample processing techniques are desirable in radiochemical analysis for environmental radioactivity monitoring, nuclear emergency preparedness, nuclear waste characterization and management during operation and decommissioning of nuclear ...
Jixin Qiao
doaj   +1 more source