Results 61 to 70 of about 309,082 (262)

Solution of thixotropic model parameters during shutdown and restart of gelled crude oil in loop

open access: yesYou-qi chuyun, 2020
Thixotropy, an important index to measure the low-temperature fluidity of waxy crude oil, is crucial to the hydraulic characteristics and safety of gelled crude oil during pipeline shutdown and restart. In the existing process of solving the parameter of
Keping ZHAI   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Model-Free Closed-Loop Control of Flow Past a Bluff Body: Methods, Applications, and Emerging Trends

open access: yesActuators
Flow past one or multiple bluff bodies is almost ubiquitous in nature and industrial applications, and its rich underlying physics has made it one of the most typical problems in fluid mechanics and related disciplines.
Feng Ren, Xin Wen, Hui Tang
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Closed parasitic flow loops and dominated loops in networks [PDF]

open access: yesInternational Journal of Operational Research, 2019
The paper raises awareness of the presence of closed parasitic flow loops in the solutions of published algorithm for maximising the throughput flow in networks. If the rooted commodity is interchangeable commodity, a closed parasitic loop can effectively be present even if the routed commodity does not physically travel along a closed loop. The closed
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Detecting and drilling in critical inclination window in slant wells by means of a two phase liquid-solid CFD model and experimental study

open access: yesKuwait Journal of Science, 2019
Build and hold from vertical section form slant wells. The hole cleaning phenomena in this wells can cause of many problems that increased the operational costs.
Mohsen Dehvedar, Parviz Moarefvand
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

The twisted gradient flow coupling at one loop

open access: yesJournal of High Energy Physics, 2019
We compute the one-loop running of the SU(N) ’t Hooft coupof twelve-flavor SU(3) gauge theoryling in a finite volume gradient flow scheme using twisted boundary conditions.
Eduardo I. Bribián   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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