Results 41 to 50 of about 3,777,755 (257)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Loop Leaping with Closures (proof appendix for conference submission) [PDF]
, 2012 Loop leaping is the colloquial name given to a form of program analysis in which summaries are derived for nested loops starting from the innermost loop and proceeding in a bottom-up fashion considering one more loop at a time.
Brauer, Jorg +3 more
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Geochemistry, Geophysics, GeosystemsTracking methane transport becomes more complicated in the deep ocean where seafloor release of methane gas bubbles occurs at the high pressures and low temperatures conducive to hydrate formation on bubble surfaces.
Alexandra M. Padilla, William F. Waite
doaj +1 more source
Applied Sciences, 2020 This study focused on gas/Newtonian and gas/non-Newtonian two-phase horizontal fluid flow behavior by analyzing their flow regime identification and flow structural analysis on a horizontal flow loop apparatus.
Munzarin Morshed +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Efficiency of Passive Open Loop Heat Removal Over Wide Range of Loop Flow Resistances – PASI Loop Tests in the EU-PASTELS Project [PDF]
, 2023 The PASI test facility, designed and constructed at LUT University, is a model of a containment cooling system using an open passive heat removal loop.
Riikonen, Vesa +4 more
core +1 more source
PLoS ONE, 2015 Sprouting angiogenesis and capillary network formation are tissue scale phenomena. There are also sub-scale phenomena involved in angiogenesis including at the cellular and intracellular (molecular) scales.
Hossein Bazmara +5 more
doaj +1 more source