Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Phase flow rate measurements of annular flows
In the international oil and gas industry multiphase annular flow in pipelines and wells is extremely important, but not well understood. This thesis reports the development of an efficient and cheap method for measuring the phase flow rates in two phase
Al-Yarubi, Qahtan
core
Shear stress preconditioning and microbubble flow pattern modulate ultrasound-assisted plasma membrane permeabilization. [PDF]
Mater Today BioMemari E, Helfield B.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Delayed Detection of Coarctation of the Aorta Causing Resistant Hypertension in Elderly With Bilateral Parvus et Tardus Renal Doppler Flow Pattern Serving as a Gateway to Diagnosis-A Case Report. [PDF]
Clin Case RepGhimire J +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Combination of an Optically Induced Dielectrophoresis (ODEP) Mechanism and a Laminar Flow Pattern in a Microfluidic System for the Continuous Size-Based Sorting and Separation of Microparticles. [PDF]
Biosensors (Basel)Chu PY, Wu AY, Tsai KY, Hsieh CH, Wu MH.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Modeling Mist to Annular Flow Development in the Discharge of a Compressor
, 2012 A model has been created to describe the development of flow leaving a compressor as it transitions from mist to annular flow. Flow parameters such as the drop size, drop speed, drop concentration, film thickness, and film velocity change as a function ...
Wujek, Scott S., Hrnjak, Predrag S.
core
Flows, Patterns and Topographies
Materia Arquitectura, 2011 Our lived landscapes are repositories of messages, of decisions taken by generations of cultural activity on the land. We can study the landscape to read our given world. But can we undertake this “landscape reading” in reverse, using its techniques to structure space, and “write” a way of living on the land The “Open City” of Ritoque has no urban ...
openaire +1 more source