Results 121 to 130 of about 973,831 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis the impact of hydrological flow patterns on hydropower generation in Haditha dam reservoir. [PDF]

Sci Rep
Tayyeh HK, Mohammed R, Hussein AM, Benzougagh B, Alasqah A, Khedher KM, Almutairi MK.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Exchanging Genes Within a City: Analysis of Pollen Flow Patterns in a Narrow Endemic Plant Species Threatened by Urbanisation. [PDF]

Ecol Evol
Delnevo N, Piotti A, van Etten EJ, Stock WD, Field DL, Byrne M.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Blood flow patterns in patients with bicuspid aortic valve undergoing different type of aortic valve replacement-computational fluid dynamics analyses and case reports. [PDF]

Cardiovasc Diagn Ther
An K, Zhu K, Liu S.
europepmc   +1 more source

Doppler Flow Patterns in HCM Patients With Apical Aneurysms Provide Insight Into Pathophysiology. [PDF]

JACC Case Rep, 2023
Sherrid MV, Massera D.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Flow patterns through side holes of venous cannula in mock circulation loop. [PDF]

Medicine (Baltimore)
Kang DH, Kim JW, Moon SH, Lee SK, Cha HJ, Byun JH, Byun JH.   +6 more
europepmc   +1 more source

Reply: Doppler Flow patterns in HCM Patients With Apical Aneurysm Provide Insight into Pathophysiology. [PDF]

JACC Case Rep, 2023
Lo Russo GV, Pepi M, Mushtaq S, Mantegazza V, Celeste F.   +4 more
europepmc   +1 more source