Results 31 to 40 of about 1,258,579 (181)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

The implementation of the vegter yield criterion and a physically based hardening rule in finite elements [PDF]

open access: yes, 1998
A new material description for sheet metal forming using Finite Elements has been developed. The description consists of a yield criterion and a hardening rule.
Carleer, B.D.   +5 more
core   +1 more source

Thermalization of plastic flow versus stationarity of thermomechanical equilibrium in SGR theory

open access: yes, 2018
We discuss issues related to thermalization of plastic flow in the context of soft glassy rheology (SGR) theory. An apparent problem with the theory in its current form is that the stationarity of thermomechanical equilibrium obtained by requiring that ...
Hoy, Robert S.
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Granular gravitational collapse and chute flow

open access: yes, 2002
Inelastic grains in a flow under gravitation tend to collapse into states in which the relative normal velocities of two neighboring grains is zero. If the time scale for this gravitational collapse is shorter than inverse strain rates in the flow, we ...
Ertas, Deniz, Halsey, Thomas C.
core   +1 more source

A transaction-based method for allocation of transmission grid cost and losses [PDF]

open access: yes, 2005
The problem of grid cost and losses allocation may be divided into independent subproblems: allocation of branch flow and losses to transactions, definition of these transactions and cost allocation to transactions.
Usaola García, Julio
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Selection-rule blockade and rectification in quantum heat transport

open access: yes, 2009
We introduce a new thermal transport phenomenon, a unidirectional selection-rule blockade, and show how it produces unprecedented rectification of bosonic heat flow through molecular or mesoscopic quantum systems.
H. Bruus, H. P. Breuer, Teemu Ojanen
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

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