Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
, 2023 Item 3642 contains images of Pyrmont, Harvey and Harris Streets, shell and gun annexe extension, gun shop, shell shop, tool room, pattern shop, heavy machine shop, fitting shop, boiler shop ...
Photographer: Unknown +1 more
core +1 more source
Non-permutation flow shop scheduling problem with preemption-dependent processing time
Cogent Engineering, 2016 In this paper, the non-permutation flow shop scheduling problem with preemption-dependent processing times is considered. A mixed integer programming formulation is proposed to tackle the problem. The optimization objective considered is the minimization
Mohsen Ziaee, Hossein Karimi
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A computational efficient optimization of flow shop scheduling problems. [PDF]
Sci Rep, 2022 Liang Z +4 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A Heuristic-Based Adaptive Iterated Greedy Algorithm for Lot-Streaming Hybrid Flow Shop Scheduling Problem with Consistent and Intermingled Sub-Lots. [PDF]
Sensors (Basel), 2023 Lu Y, Tang Q, Pan Q, Zhao L, Zhu Y.
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Dataset of metaheuristics for the flow shop scheduling problem with maintenance activities integrated. [PDF]
Data Brief, 2021 Branda A +3 more
europepmc +1 more source