Results 51 to 60 of about 5,921,354 (245)

Computer simulation based analysis of transient two-phase thermal evolutions during multiprobe cryosurgery of hepatic tissues embedded without or with blood vessels

International Journal of Thermofluids
Cryosurgery is demarcated as cell annihilation by freezing temperature yielded through a cryogenic probe. Thermal distributions nearby the adjacent blood vessels can impede the iceball evolution and surgery success.
Sorowar Hossain, S. M. Chapal Hossain, Mohammad Ferdows, Md. Zavid Iqbal Bangalee, Md. Shariful Alam   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

TRANSONIC AFTERBODY SIMULATION [PDF]

, 2007
One challenge of numerical investigations of unsteady super- and hypersonic flow fields is the study of turbulent wake flow and the interaction with nozzle sections at modern launcher configurations.
Filimon, Alexander, Lüdeke, Heinrich
core  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

The user’s guide to the Eilmer4 flow simulation program

, 2017
Eilmer4 is a program for the simulation of transient, compressible flow in two and three spatial dimensions. It has a preparation mode that can be used to set up a database of simulation parameters, a multiblock grid defining the flow domain and an ...
Veeraragavan, Anand, Jahn, Ingo, Gollan, Rowan J., Jacobs, Peter A.   +3 more
core   +1 more source

Investigation into the Computational Analysis of High–Speed Microjet Hydrogen–Air Diffusion Flames

Fire
High-speed microjet hydrogen–air diffusion flames are investigated computationally. The focus is on the prediction of the so-called bottleneck phenomenon.
Ali Cemal Benim
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Numerical Analysis of Turbulent Combustion in a Model Swirl Gas Turbine Combustor

Journal of Combustion, 2016
Turbulent reacting flows in a generic swirl gas turbine combustor are investigated numerically. Turbulence is modelled by a URANS formulation in combination with the SST turbulence model, as the basic modelling approach.
Ali Cemal Benim, Sohail Iqbal, Franz Joos, Alexander Wiedermann   +3 more
doaj   +1 more source