Results 31 to 40 of about 156,703 (265)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Open GeosciencesOn December 18, 2023, the M S 6.2 Jishishan earthquake triggered a large-scale liquefaction disaster of loess sites in Jintian and Caotan villages, Zhongchuan town, Minhe County, Haidong City, Qinghai Province.
Wang Yi +6 more
doaj +1 more source
Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Математичне моделювання, інформаційні технології, автоматизовані системи управління, 2019 One of actual issues in the field of gas dynamics of piston engines which concerns the analytical estimation of influence of structural and regime parameters on the processes of flowing of gases through gas distribution mechanisms is examined.
Oleksandr I. Voronkov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Analisis Tipe Dan Bidang Gelincir Longsor Di Kabupaten Gorontalo Utara
Jambura Geoscience Review, 2021 The purpose of this study was to determine the type of landslides and analyze the landslide slip in North Gorontalo District, Gorontalo Province using the geoelectric method.
La Ode Juni Akbar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Journal of Harbin University of Science and TechnologyIn view of the problem that the static characteristics of the slide valve can affect the performance of the hydraulic servo system，the software simulation method is mainly used to analyze the pressure，flow velocity and flow distribution law of the ...
WU Yueneng +5 more
doaj +1 more source
Frontiers in Earth Science, 2022 The progressive failure of earthen check dams triggered by upstream flow is common in loess gullies on the Loess Plateau of China. However, studies on the formation mechanism of progressive failure are still unclear.
Yanbo Zhu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source