Results 71 to 80 of about 399,995 (266)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Two-Field Prismatic Finite Element Under Elasto-Plastic Deformation

Structural Mechanics of Engineering Constructions and Buildings
For elasto-plastic analysis of structures at a particular load step, a mixed finite element in the form of a prism with triangular bases was obtained. Displacement increments and stress increments were taken as nodal unknowns.
Rumia Z. Kiseleva, Vitaliy V. Ryabukha, Natalia A. Kirsanova, Yuriy V. Klochkov, Anatoliy P. Nikolaev   +4 more
doaj   +1 more source

Between a Troll and a Hard Place: The Demand Framework’s Answer to One of Gaming’s Biggest Problems

Media and Communication, 2019
The demand framework is commonly used by game scholars to develop new and innovative ways to improve the gaming experience. However, the present article aims to expand this framework and apply it to problematic gaming, also known as trolling.
Christine L. Cook
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Unstable flow theory and modeling,

Mathematical and Computer Modelling, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Flipping and gamifying university’s online English preparation courses: Understanding learner flow state and autonomy

Studies in English Language and Education
This study utilized a sequential exploratory mixed methods design to examine the synergistic effects of flipped and gamified learning on students’ flow state and autonomy in a fully synchronous online English preparation course at an Indonesian ...
Safnil Arsyad, Budi Waluyo, Leffi Noviyenty, Amrullah Amrullah, Paidi Gusmuliana, Rismar Riansih   +5 more
doaj   +1 more source

Connecting the Dots: Haptic Imagery's Sequential Impact via Serial Mediation in Social Commerce Applications [PDF]

International Journal of Business Science and Applied Management
By integrating the Theory of Interactive Media Effects (TIME) and flow theory, this research investigates the influence of haptic imagery on users' experiences and behavioural intentions within the context of Social Commerce Applications (SCAs).
Chong, S., Ng, S., Basha, N.K., & Lim, X.
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source