Results 231 to 240 of about 2,303,338 (260)

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang   +9 more
wiley   +1 more source

H3K4 Methylation Readers in Plants: Recognition Mechanisms and Biological Functions. [PDF]

open access: yesInt J Mol Sci
Li Y   +9 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

Mineral nutrients as regulators of plant flowering time: A molecular perspective. [PDF]

open access: yesJ Integr Plant Biol
Zeng H   +7 more
europepmc   +1 more source

Pleiotropic effects of "flowering" genes in transgenic poplar

open access: yes, 2013
Fladung, Matthias   +3 more
core  

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