Results 21 to 30 of about 100,185 (199)
Mean curvature flows and isotopy problems [PDF]
, 2012 In this note, we discuss the mean curvature flow of graphs of maps between Riemannian manifolds. Special emphasis will be placed on estimates of the flow as a non-linear parabolic system of differential equations.
Wang, Mu-Tao
core
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Mean curvature flow and quasilocal mass for two-surfaces in Hamiltonian General Relativity
, 2006 A family of quasilocal mass definitions that includes as special cases the Hawking mass and the Brown-York ``rest mass'' energy is derived for spacelike 2-surfaces in spacetime.
Arnowitt R. +11 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Sharp Entropy Bounds for Self-Shrinkers in Mean Curvature Flow
, 2018 Let $M\subset {\mathbf R}^{m+1}$ be a smooth, closed, codimension-one self-shrinker (for mean curvature flow) with nontrivial $k^{\rm th}$ homology. We show that the entropy of $M$ is greater than or equal to the entropy of a round $k$-sphere, and that ...
Hershkovits, Or, White, Brian
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Ancient solutions of geometric flows with curvature pinching
, 2018 We prove rigidity theorems for ancient solutions of geometric flows of immersed submanifolds. Specifically, we find pinching conditions on the second fundamental form that characterize the shrinking sphere among compact ancient solutions for the mean ...
Risa, Susanna, Sinestrari, Carlo
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source