Results 21 to 30 of about 101,218 (224)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Mean curvature flow and quasilocal mass for two-surfaces in Hamiltonian General Relativity
, 2006 A family of quasilocal mass definitions that includes as special cases the Hawking mass and the Brown-York ``rest mass'' energy is derived for spacelike 2-surfaces in spacetime.
Arnowitt R. +11 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Fourth-order flows in surface modelling [PDF]
, 2013 This short article is a brief account of the usage of fourth-order curvature flow in surface ...
Kang, Ty
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
On the Variational Approximation of Combined Second and Fourth Order Geometric Evolution Equations
SIAM Journal on Scientific Computing, 2007 We present a variational formulation of combined motion by minus the Laplacian of curvature and mean curvature flow, as well as related flows. The proposed scheme covers both the closed curve case and the case of curves that are connected via triple or ...
J. Barrett, H. Garcke, R. Nürnberg
semanticscholar +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Mean curvature flows and isotopy problems [PDF]
, 2012 In this note, we discuss the mean curvature flow of graphs of maps between Riemannian manifolds. Special emphasis will be placed on estimates of the flow as a non-linear parabolic system of differential equations.
Wang, Mu-Tao
core
Sharp Entropy Bounds for Self-Shrinkers in Mean Curvature Flow
, 2018 Let $M\subset {\mathbf R}^{m+1}$ be a smooth, closed, codimension-one self-shrinker (for mean curvature flow) with nontrivial $k^{\rm th}$ homology. We show that the entropy of $M$ is greater than or equal to the entropy of a round $k$-sphere, and that ...
Hershkovits, Or, White, Brian
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source