Results 21 to 30 of about 101,246 (190)

Uniqueness of asymptotically conical tangent flows

, 2019
Singularities of the mean curvature flow of an embedded surface in R^3 are expected to be modelled on self-shrinkers that are compact, cylindrical, or asymptotically conical.
Chodosh, Otis, Schulze, Felix
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mean Curvature Flow on Ricci Solitons

, 2010
We study monotonic quantities in the context of combined geometric flows. In particular, focusing on Ricci solitons as the ambient space, we consider solutions of the heat type equation integrated over embedded submanifolds evolving by mean curvature ...
Bakas I, Cao H D Zhu X P, Chow B, Efstratios Tsatis, Fateev V A Onofri E, Hamilton R, Huisken G, Kleiner B Lott J, Mantegazza C Magni A Tsatis E, Morgan J Tian G, Ni L, Perelman G, Perelman G, Perelman G, Zamolodchikov A B, Zamolodchikov A B   +15 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Particle transport in turbulent curved pipe flow

, 2016
Direct numerical simulations (DNS) of particle-laden turbulent flow in straight, mildly curved and strongly bent pipes are performed in which the solid phase is modelled as small heavy spherical particles. A total of seven populations of dilute particles
Brandt, Luca, Noorani, Azad, Sardina, Gaetano, Schlatter, Philipp   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Direct Numerical Simulation of turbulent Taylor-Couette flow

, 2007
The direct numerical simulation (DNS) of the Taylor--Couette flow in the fully turbulent regime is described. The numerical method extends the work by Quadrio & Luchini (Eur. J. Mech.
Andereck, Batchelor, Bech, Bilgen, Coles, Davide Pirrò, De Graaf, Del Álamo, Dubrulle, Eckhardt, Fasel, Haim, Hamilton, Kim, Komminaho, Koschmieder, Lathrop, Lele, Lewis, Luchini, Maurizio Quadrio, Moser, Moser, Orszag, Panton, Patel, Quadrio, Schultz, Smith, Snyder, Tagg, Taylor, Thomas, Townsend, Townsend   +34 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Volume preserving flow by powers of symmetric polynomials in the principal curvatures

, 2018
We study a volume preserving curvature flow of convex hypersurfaces, driven by a power of the $k$-th elementary symmetric polynomial in the principal curvatures.
Bertini, Maria Chiara, Sinestrari, Carlo
core   +1 more source