Results 21 to 30 of about 73,149,372 (220)
On the Structure of Singularities of Weak Mean Curvature Flows with Mean Curvature Bounds [PDF]
, 2023 This paper studies singularities of mean curvature flows with integral mean curvature bounds $H \in L^\infty L^p_{loc}$ for some $p \in ( n, \infty]$. For such flows, any tangent flow is given by the flow of a stationary cone $\mathbf{C}$.
Stolarski, Maxwell
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Stability results for nonlocal geometric evolutions and limit cases for fractional mean curvature flows [PDF]
, 2021 We introduce a notion of uniform convergence for local and nonlocal curvatures. Then, we propose an abstract method to prove the convergence of the corresponding geometric flows, within the level set formulation.
Ponsiglione M. +7 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Lectures on Mean Curvature Flow and Related Equations
, 1998 63 pages. These unpublished lecture notes were written by Tom Ilmanen (1961-2025) in 1995. They are posted on arXiv with the permission of his family.
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Lectures on mean curvature flows
, 2002 "Mean curvature flow" is a term that is used to describe the evolution of a hypersurface whose normal velocity is given by the mean curvature. In the simplest case of a convex closed curve on the plane, the properties of the mean curvature flow are ...
Zhu, Xi-Ping, Xi-Ping Zhu
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Modelling of turbulent swirling flows [PDF]
, 2004 This thesis investigates the predictability of non-reacting and reacting anistropic turbulent, swirling flows using popular turbulence models with a robust numrical procedure. The performance of these turbulence models is assessed and compared against
Jones, Lee Nicholas
core +4 more sources