Results 51 to 60 of about 73,149,372 (220)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

A pointwise approach to rigidity of almost graphical self-shrinking solutions of mean curvature flows

open access: yes, 2018
We prove rigidity of any properly immersed noncompact Lagrangian shrinker with single valued Lagrangian angle for Lagrangian mean curvature flows. Our pointwise approach also provides an elementary proof to the known rigidity results for graphical and ...
Yu Yuan, Yingfeng Xu, Dongsheng Li
core   +1 more source

A varifold formulation of mean curvature flow with Dirichlet or dynamic boundary conditions [PDF]

open access: yes, 2018
We consider the sharp interface limit of the Allen-Cahn equation with Dirichlet or dynamic boundary conditions and give a varifold characterization of its limit which is formally a mean curvature flow with Dirichlet or dynamic boundary conditions.
Takasao, Keisuke   +4 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

On area comparison and rigidity involving the scalar curvature [PDF]

open access: yes
In this thesis we study the effects of lower bounds for the curvature of a Riemannian manifold M on the geometry and topology of closed, minimal hypersurfaces.
Moraru, Vlad
core  

Volume-Preserving Mean Curvature and Willmore Flows with Line Tension [PDF]

open access: yes, 2013
We show the short-time existence and uniqueness of solutions for the motion of an evolving hypersurface in contact with a solid container driven by volume-preserving Mean Curvature Flow (MCF) and line tension effect on the boundary.
Müller, Lars
core   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Tangent Flows in Mean Curvature Flow

open access: yes
This thesis investigates the uniqueness and asymptotic behavior of tangent flows arising in mean curvature flow, where singularities naturally develop over time.
Sourav Ghosh (23723244)
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

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