Results 31 to 40 of about 47,013 (254)

An Optimised Live Attenuated Influenza Vaccine Ferret Efficacy Model Successfully Translates H1N1 Clinical Data

Vaccines
Between 2013 and 2016, the A/H1N1pdm09 component of the live attenuated influenza vaccine (LAIV) produced instances of lower-than-expected vaccine effectiveness.
Katarzyna E. Schewe, Shaun Cooper, Jonathan Crowe, Steffan Llewellyn, Lydia Ritter, Kathryn A. Ryan, Oliver Dibben   +6 more
doaj   +1 more source

Human Influenza A(H7N9) Virus Infection Associated with Poultry Farm, Northeastern China

Emerging Infectious Diseases, 2014
We report on a case of human infection with influenza A(H7N9) virus in Jilin Province in northeastern China. This case was associated with a poultry farm rather than a live bird market, which may point to a new focus for public health surveillance and ...
Ming Fan, Biao Huang, Ao Wang, Liquan Deng, Donglin Wu, Xinrong Lu, Qinglong Zhao, Shuang Xu, Fiona Havers, Yanhui Wang, Jing Wu, Yuan Yin, Bingxin Sun, Jianyi Yao, Nijuan Xiang   +14 more
doaj   +1 more source

Vers une signature spatiale de la vulnérabilité épidémiologique en France : l'exemple de la grippe

Physio-Géo, 2010
The epidemiology of infectious diseases is in the heart of the concerns of numerous authorities of Public health. This theme was reactivated by the anguishes generated by the Severe Acute Respiratory Syndrome (SARS) or more recently by the fears of a flu-
Benjamin Lysianuk, Martine Tabeaud
doaj   +1 more source

Replication in human cells supersedes serum antigenic match for the in vivo efficacy of an A/H1N1pdm09 LAIV virus

npj Vaccines
For FluMist®/Fluenz live attenuated influenza vaccine (LAIV), efficient virus replication in human nasal epithelial cells (hNEC) is an important factor in vaccine effectiveness (VE).
Steffan Llewellyn, Katarzyna E. Schewe, Sameer Ayaz, David Burbidge, Shaun Cooper, Jonathan Crowe, Sarah Dodd, Jemma Shapanis, Katie Tudor, Kathryn Ryan, Lauren Parker, Oliver Dibben   +11 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Use of Artificial Intelligence to Triage Patients with Flu-Like Symptoms Using Imaging in Non-COVID-19 Hospitals during COVID-19 Pandemic: An Ongoing 8-Month Experience

Indian Journal of Radiology and Imaging, 2021
Background Evaluation of suspected coronavirus disease-2019 (COVID-19) patient is a diagnostic dilemma as it commonly presents like influenza in early stages.
Atul Kapoor, Aprajita Kapoor, Goldaa Mahajan   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Comparing the Attitude toward the COVID-19 and the 2020/21 and 2019/20 Flu Vaccination Campaigns among Italian Healthcare Workers

Vaccines, 2021
Background: While the uptake of the COVID-19 vaccine among healthcare workers (HCWs) is suboptimal, vaccine hesitancy has not been characterized in detail in this population.
Giulia Collatuzzo, Riccardo Melloni, Chiara Zanotti, Giulio de Simone, Danila Pilastro, Vittorio Lodi, Paolo Boffetta   +6 more
doaj   +1 more source