Results 261 to 270 of about 82,111 (287)
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Spectral characterization of fluconazole
Journal of Pharmaceutical and Biomedical Analysis, 1996Reference 1H, 19F and 13C NMR, mass, IR and Raman spectra are provided to the open literature for the first time for the potent antifungal agent fluconazole, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl++ +)-1H-1,2, 4-triazole-1-ethanol. The 1H, 19F and 13C NMR spectra were analyzed in detail to attribute shifts, including 19F chemical
Brian Dawson +3 more
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Fluconazole (Diflucan®): a review
International Journal of Antimicrobial Agents, 1993Fluconazole is a triazole antifungal agent available for oral or intravenous use in the treatment of a number of localized and disseminated mycoses. Animal models have shown in vivo activity against infections caused by Candida spp. and Crytococcus neoformans.
Françoise Meunier, Mark Zervos
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Accumulation of fluconazole in sebum
Int. Journal of Clinical Pharmacology and Therapeutics, 2001Concentrations of fluconazole in sebum and plasma were determined in 2 parallel groups, each consisting of 8 healthy subjects. Group 1 received a 150 mg fluconazole capsule once weekly over a period of 4 weeks, Group 2 was administered 2 capsules/week, corresponding to 300 mg fluconazole/week for 4 weeks. Sampling was performed immediately before and 5
H. Laufen +3 more
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European Journal of Clinical Pharmacology, 1997
Midazolam is a short-acting benzodiazepine hypnotic extensively metabolized by CYP3A4 enzyme. Orally ingested azole antimycotics, including fluconazole, interfere with the metabolism of oral midazolam during its absorption and elimination phases. We compared the effect of oral and intravenous fluconazole on the pharmacokinetics and pharmacodynamics of ...
Pertti J. Neuvonen +2 more
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Midazolam is a short-acting benzodiazepine hypnotic extensively metabolized by CYP3A4 enzyme. Orally ingested azole antimycotics, including fluconazole, interfere with the metabolism of oral midazolam during its absorption and elimination phases. We compared the effect of oral and intravenous fluconazole on the pharmacokinetics and pharmacodynamics of ...
Pertti J. Neuvonen +2 more
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Clinical Pharmacokinetics of Fluconazole
Clinical Pharmacokinetics, 1993Fluconazole was recently developed for the treatment of superficial and systemic fungal infections. Triazole groups and insertion of 2 fluoride atoms increase the polarity and hydrosolubility of the drug, allowing it to be used in a parenteral form. Bioassay methods using Candida pseudotropicalis as a test organism were the first techniques used for ...
Jean-Philippe Ryckelynck +1 more
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Developmental and transplacental genotoxicology: Fluconazole
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008Over the last 40 years mankind has been facing new types of radiochemical environmental settings with every decade. During the last decade, biomonitoring was additionally focused on assessing associations between environmental exposure(s) and both early and late biological effects in children.
Boris Mildner +9 more
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Fluconazole use and safety in the nursery
Early Human Development, 2012Fluconazole is a triazole antifungal agent that is widely used in the nursery. It is available in both intravenous and oral formulation, and is active against most of the fungal pathogens that require treatment when retrieved from culture samples in neonatal intensive care units.
E. Castagnola +7 more
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Treatment of Coccidioidal Meningitis with Fluconazole
Clinical Infectious Diseases, 1990Fluconazole was administered at doses of 50-400 mg/d to 18 patients (15 men, three women) with coccidioidal meningitis. After a mean duration of treatment of 9.8 months, 10 (67%) of 15 assessable patients had responded, one (7%) of 15 had partially responded, and four (27%) of 15 had not responded to therapy.
Tucker, R.M. +10 more
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