Results 31 to 40 of about 8,152 (213)
Process Regulation and Properties of Plasma-Cladded Layers on Tubular Copper Components [PDF]
Cailiao BaohuTubular copper components are core components for fluid transportation and heat exchange and are widely used in industrial fields such as energy，metallurgy，and chemical engineering.
ZHANG Chao, CHENG Sheng, TU Demei, ZHAO Lulu, BAI Dan, WANG Dongsheng, CHEN Shoudong
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Вестник Донского государственного технического университета, 2018 The results of development and experimental tests of vibrofinishing (abrading) cylindrical details by riding on a flat fluctuating surface are presented.
Nikolay V. MATEGORIN +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Teshugang, 2017 The surface transversal cracks occur on steel 65Mn (/%： 0.65C, 0.24Si, 1. 00Mn, 0.014P, 0.006S) 2.5mm X 10mm flat wire cold-drawn and rolled by φ6.5mm Coil.
贾旭岗, 杨晓奇, 梁世勇
doaj
Confined water in low-dimensional materials: structural, spectroscopic, and transport phenomena
Academia NanoWater confined in low-dimensional materials exhibits structural and dynamical behaviors that diverge fundamentally from bulk liquid water.
Ziwei Wang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source