Results 101 to 110 of about 1,062,005 (252)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Influence of Fluid-Structure Interaction on Microcantilever Vibrations: Applications to Rheological Fluid Measurement and Chemical Detection [PDF]
, 2013 At the microscale, cantilever vibrations depend not only on the microstructure’s properties and geometry but also on the properties of the surrounding medium.
Brand, Oliver +7 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Some Numerical Approaches to Solve Fluid Structure Interaction Problems in Blood Flow
Abstract and Applied Analysis, 2014 Some numerical approaches to solve fluid structure interaction problems in blood flow are reviewed. Fluid structure interaction is the interaction between a deformable structure with either an internal or external flow.
Aik Ying Tang, Norsarahaida Amin
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Development and Verification of Coupled Fluid–Structure Interaction Solver
ComputationRecent trends in aeroelastic analysis have shown a great interest in understanding the role of shock boundary layer interaction in predicting the dynamic instability of aircraft structural components at supersonic and hypersonic flows.
Avery Schemmel +4 more
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Progress in Fluid-Structure Interaction Research of Membrane Wings
气体物理Flexible membrane wings, as one of the most fundamental types of bio-inspired flexible wings, can leverage the fluid-structure interaction （FSI） effect.
Xi HE, Qinfeng GUO, Jinjun WANG
doaj +1 more source
Finite element solution of transient fluid-structure interaction problems [PDF]
A finite element approach using NASTRAN is developed for solving time-dependent fluid-structure interaction problems, with emphasis on the transient scattering of acoustic waves from submerged elastic structures.
Cheng, Raymond S. +2 more
core +1 more source