Results 31 to 40 of about 239,084 (199)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Study of modal analysis based on fluid-structure interaction
Revista IBRACON de Estruturas e Materiais, 2018 In this work, a coupled fluid-structure problem is approached, comparing the result with the modal analysis of a structure. The objective of this work is to analyze the physical phenomenon of fluid-structure interaction of a flexible structure. For this,
M. PEGORARO, F. A. A. GOMES, P. R. NOVAK
doaj +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Low Reynolds Number Effect on Energy Extraction Performance of Semi-Passive Flapping Foil
Journal of Applied Fluid Mechanics, 2018 In this paper, 2-D numerical solution scheme is used to study the performance of semi-passive flapping foil flow energy harvester at Reynolds numbers ranging from 5000 to 50,000.
A. Javed, K. Djidjeli, J. T. Xing
doaj
Numerical simulation of fluid–structure interaction with SPH method
The Journal of Engineering, 2020 Smoothed particle hydrodynamics (SPH) is a meshfree, Lagrangian, particle method, which combines the advantages of Euler and Lagrangian method and has special advantages in simulating violent non-linear fluid–structure interaction problems. In this study,
Yu Yang, Jiaru Shao
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Applied and Computational Mechanics, 2017 A fixed point algorithmis proposed to solve a fluid-structure interaction problem with the supplementary constraint that the structure displacements are limited by a rigid obstacle.
Yakhlef O., Murea C.M.
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source