Results 41 to 50 of about 239,054 (234)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fluid-Structure Interaction In Mouth-Breathing Patients

International Dental Journal
Aim or purpose: This research uses the flow-solid coupling method to investigate the formation mechanism of mouth-breathing-related malformations. Materials and methods: This study developed a fluid-structure coupled finite element model of the upper ...
Wei Ji, Linkun Zhang, Yuan Luo
doaj   +1 more source

Fluid-Structure Interaction Mechanisms for Close-In Explosions

Shock and Vibration, 2000
This paper examines fluid-structure interaction for close-in internal and external underwater explosions. The resulting flow field is impacted by the interaction between the reflected explosion shock and the explosion bubble.
Andrew B. Wardlaw Jr., J. Alan Luton
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Study of modal analysis based on fluid-structure interaction

Revista IBRACON de Estruturas e Materiais, 2018
In this work, a coupled fluid-structure problem is approached, comparing the result with the modal analysis of a structure. The objective of this work is to analyze the physical phenomenon of fluid-structure interaction of a flexible structure. For this,
M. PEGORARO, F. A. A. GOMES, P. R. NOVAK
doaj   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Low Reynolds Number Effect on Energy Extraction Performance of Semi-Passive Flapping Foil

Journal of Applied Fluid Mechanics, 2018
In this paper, 2-D numerical solution scheme is used to study the performance of semi-passive flapping foil flow energy harvester at Reynolds numbers ranging from 5000 to 50,000.
A. Javed, K. Djidjeli, J. T. Xing
doaj  

Numerical simulation of fluid–structure interaction with SPH method

The Journal of Engineering, 2020
Smoothed particle hydrodynamics (SPH) is a meshfree, Lagrangian, particle method, which combines the advantages of Euler and Lagrangian method and has special advantages in simulating violent non-linear fluid–structure interaction problems. In this study,
Yu Yang, Jiaru Shao
doaj   +1 more source