Results 81 to 90 of about 5,359,566 (332)
A fluid approximation for large-scale service systems [PDF]
ACM SIGMETRICS Performance Evaluation Review, 2010 We introduce and analyze a deterministic fluid model that serves as an approximation for the Gt/GI/st + GI manyserver queueing model, which has a general time-varying arrival process (the Gt), a general service-time distribution (the first GI), a time-dependent number of servers (the st) and allows abandonment from queue according to a general ...
Yunan Liu, Ward Whitt
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On the power of (even a little) resource pooling
Stochastic Systems, 2012 We propose and analyze a multi-server model that captures a performance trade-off between centralized and distributed processing. In our model,a fraction p of an available resource is deployed in a centralized manner (e.g., to serve a most-loaded station)
Kuang Xu, John N. Tsitsiklis
doaj
Assessment of fluid neutral models for a detached ITER case
Nuclear Materials and Energy, 2017 We compare the plasma sources (particle, parallel momentum and ion energy) due to plasma-neutral interactions computed with different fluid neutral models with the sources from a Monte Carlo simulation of the kinetic neutral equation.
N. Horsten +3 more
doaj +1 more source
Transient generalized Taylor-Couette flow: a semi-analytical approach
Journal of Taibah University for Science, 2020 Semi-analytical solution of transient generalized Taylor-Couette flow of a viscous, incompressible fluid between the gaps of concentric rotating cylinders under applied azimuthal pressure gradient ispresented.
Basant Kumar Jha, Yahaya Jibrin Danjuma
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Computational fluid dynamics-based hull form optimization using approximation method
Engineering Applications of Computational Fluid Mechanics, 2018 With the rapid development of the computational technology, computational fluid dynamics (CFD) tools have been widely used to evaluate the ship hydrodynamic performances in the hull forms optimization.
Shenglong Zhang +4 more
doaj +1 more source