Results 131 to 140 of about 5,359,566 (332)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Asymptotic Approximation of the Nonsteady Micropolar Fluid Flow through a Circular Pipe

open access: yes, 2018
We study the nonsteady flow of a micropolar fluid through a thin cylindrical pipe. The asymptotic behaviour of the flow is found via asymptotic analysis with respect to the small parameter ϵ, representing the pipe’s thickness.
Igor Pažanin, Marko Radulović
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

The Optimal Transportation Meshfree Method for General Fluid Flows and Strongly Coupled Fluid-Structure Interaction Problems [PDF]

open access: yes, 2009
This thesis develops a novel meshfree numerical method for simulating general fluid flows. Drawing from concepts in optimal mass transport theory and in combination with the notion of material point sampling and meshfree interpolation, the optimal ...
Habbal, Feras
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

open access: yesMolecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

A Transient Response Approximation for Noncircular Fluid Transmission Lines

open access: yes, 1976
A method is given for determining the transient response approximation for noncircular fluid transmission lines. The results are presented in terms of a characteristic frequency which depends only on the laminar viscous steady flow resistance and ...
M. E. Franke, J. T. Karam, E. F. Moore
core   +1 more source

Reproductive solution for grade-two fluid model in two dimensions

open access: yesRevista Integración, 2009
We treat the existence of reproductive solution (weak periodic solution) of a second-grade fluid system in two dimensions, by using the Galerkin approximation method and compactness arguments.
L. Friz   +2 more
doaj   +4 more sources

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