Results 81 to 90 of about 8,648,195 (265)
Fluid responsiveness in pediatrics: an unsolved challenge
Frontiers in AnesthesiologyPredicting fluid responsiveness is a major challenge in the pediatric population as vascular and pulmonary compliance differ from the adults. However it is a crucial thing to avoid the harmful fluid overload.
F. Escribá Alepuz +10 more
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2014 In today’s world of big data, metric-driven performance standards, and value-based care, clinicians rely upon a range of quality metrics to support decision-making and promote desirable outcomes.
Jennifer E, Flythe, M Alan, Brookhart
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Issue and challenges of fluid removal in the critically ill [PDF]
British Journal of Anaesthesia, 2014 Theadministrationofi.v.fluidsandi.v.sodiumis,togetherwith the administration of oxygen, the most common medical intervention in the critically ill. It can take the form of fluid resuscitation with single or intermittent boluses of significant amounts of fluid, or be implemented as continuous slow volume infusion or as a combination of both or as i.v ...
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Perioperative fluid management: From physiology to improving clinical outcomes
Indian Journal of Anaesthesia, 2017 Perioperative fluid management is a key component in the care of the surgical patient. It is an area that has seen significant changes and developments, however there remains a wide disparity in practice between clinicians.
Victoria A Bennett, Maurizio Cecconi
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Efficacy of Changes in Pulse Pressure Variation During Tidal Volume Challenge Test to Predict Fluid Responsiveness in Low Tidal Volume Ventilated Critically ill Patients [PDF]
Al-Azhar International Medical JournalBackground: Fluid administration is one of the first-line therapy interventions used to reverse tissue hypoperfusion during acute circulatory failure.
Saied Ali +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source