Results 51 to 60 of about 506,571 (263)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fluid Field and Temperature Field Investigation of Traction Motor in Mine Truck

Kongzhi Yu Xinxi Jishu, 2015
According to hydromechanics and heat transfer theory, a physical model of three-dimensional fluid and temperature coupled field was established for JD192 electric wheel traction motor of mine truck.
MENG Fandong, LI Huaxiang, JING Ruikang
doaj  

Change of water saturation in tight sandstone gas reservoirs near wellbores

Natural Gas Industry B, 2018
Tight sandstone gas reservoirs commonly contain water, so liquid loading often appears near wellbores, leading to production decline and even shutdown of gas wells.
Hongyu Ma, Shusheng Gao, Liyou Ye, Huaxun Liu, Wei Xiong, Jianglong Shi, Lin Wang, Kang Wu, Qingshan Qi, Chunqiu Zhang   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Comparison and Analysis of Thermal Calculation Methods for Fan-cooled Permanent Magnet Motor

Kongzhi Yu Xinxi Jishu, 2016
In order to comparatively analyze the feasibility of different thermal calculation methods on thermal design and engineering application of motor, based on a fan-cooled permanent magnet motor, it analyzed the flow of fan, the fluid field and temperature ...
YANG Jinxia, LI Weiye, ZOU Yulin, WU Jiangquan   +3 more
doaj  

Fluid Field and Temperature Field Analysis of High Speed Magnetic Field Modulated Gears

Jixie chuandong, 2023
When a high speed magnetic field modulated gear is working, eddy current loss and wind friction loss will occur in permanent magnet and magnet block. In order to study the flow field and temperature field in small gaps of high speed magnetic gears, a ...
Cheng Wenjie, Lu Huize, Xiao Ling, Li Ming   +3 more
doaj  

Numerical study of hydrofoil tip vortex fluid field

Zhongguo Jianchuan Yanjiu, 2017
Three different models,k-ω,DES and LES,are conducted in the analysis of the tip vortex flow field. In order to reduce the discrete error induced by the grid,mesh refinement is applied to the area of the tip vortex core in numerical simulations.
PU Jijun, XIONG Ying
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Model and application of CO2-EOR injection and production parameters for high pour-point oil reservoirs: A case study of SUBEI A reservoir

Unconventional Resources
Addressing the poor waterflooding performance (characterized by high injection pressure and high water cut) in the high-viscosity oil reservoir of Block A, Eastern China, this study systematically investigated the impact mechanisms of CO2 flooding ...
Wei Xia, Xiaowei Zhao, Qiu Li, Pan Wang, Rui Xu, Jiangtao Wu   +5 more
doaj   +1 more source