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The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The base (Cu–Pb–Zn) and precious metals (Ag±Au) mineralization at the No. 4 anomaly of Golojeh deposit occurred in volcanic and sub–volcanic Eocene–Oligocene host rocks, in the central part of the Tarom–Hashtjin zone.
Behzad Mehrab +2 more
doaj
Characteristics and carbon stable isotopes of fluids in the Southern Kerala granulites and their bearing on the source of CO2 [PDF]
Carbon dioxide-rich inclusions commonly occur in the banded charnockites and khondalites of southern Kerala as well as in the incipient charnockites formed by desiccation of gneisses along oriented zones.
Harris, N. B. W. +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Decoupling of fluids and fluid‐mobile elements during shallow subduction: Evidence from halogen‐rich andesite melt inclusions from the Izu arc volcanic front [PDF]
Susanne M. Straub, Graham D. Layne
openalex +1 more source

