Results 161 to 170 of about 1,022,309 (304)

Restrictive versus standard intravenous fluid therapy and NTproBNP in ICU patients with septic shock - a sub-study of the randomised CLASSIC trial. [PDF]

BMC Anesthesiol
Christensen J, Sivapalan P, Meyhoff TS, Järnbert-Pettersson H, Perner A, Møller MH, Lange T, Hjortrup PB, Joelsson-Alm E, Jonmarker S, Sjöberg F, Mårtensson J, Gladh AH, Cronhjort M.   +13 more
europepmc   +1 more source

Evaluating Fluid-Host Post Entrapment Interaction in UHP Fluid Inclusions [PDF]

Goldschmidt Abstracts, 2020
MAFFEIS ANDREA, FERRANDO SIMONA, CASTELLI DANIELE, GROPPO CHIARA, FREZZOTTI MARIA LUCE   +4 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Liberal Versus Restrictive Fluid Therapy in the Early Management of Sepsis and Septic Shock: A Systematic Review. [PDF]

Cureus
Rojas-Landa CA, Flores-Valdes JR, Ascencio-Romo A, Guevara-Olivera R, Sánchez-Bertado SC, Marquez-Prado KY, Montelongo-Quevedo M, Mena-González DM, Reyes-Abundis DC, Rojas Landa BA.   +9 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Biomarkers in Alzheimer's disease clinical trials: 2025. [PDF]

Alzheimers Dement (N Y)
Osse AML, Zhou Y, Kinney JW, Hooyman A, Sengupta A, Fonseca J, Burstein AH, Owen M, Nisenbaum L, Fillit HM, Cheng F, Cummings JL.   +11 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Process and forces of tight-sandstone gas charging in the Shihezi formation (P₂x¹) Dongsheng gas field, northern Ordos Basin China. [PDF]

Sci Rep
Cao Q, He F, Zhang W, Ye J, Lu Y, Liu Y, Yu H, An C, Sun L.   +8 more
europepmc   +1 more source