Results 61 to 70 of about 2,324,141 (302)

Insights into the Transformation Patterns of Overmature, Organic-Rich Shale Reservoirs under High-Temperature Conditions: Evidence from Physical Experiments

Yankuang ceshi
The efficient development of shale oil and gas is crucial for China’s energy security. Shale exhibits characteristics such as well-developed bedding planes, strong heterogeneity, low porosity, and low permeability. Previous studies have demonstrated that
Yangbing LI, Jianqi CHEN, Weiqiang HU, Xueqing LIU, Litao MA, Panpan LI, Chenchen LI   +6 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

New Insights into How the Rupture Radius of Deep Fault Rupture Affects the Magnitude of Induced Earthquakes

Applied Sciences
Underground fluid injection is regarded as one of the important factors inducing seismic activity. This study therefore proposes a method to predict the maximum damage area and seismic magnitude induced by fluid injection, in order to quantify the ...
Youquan Huang, Cuilong Kong, Dawei Deng, Yu Wang, Baohuai Hou, Peng Liu, Tianyu Chen, Xiaoyu Zhang   +7 more
doaj   +1 more source

A method to experimentally investigate injection-induced activation of fractures

Journal of Rock Mechanics and Geotechnical Engineering, 2020
Natural fractures are generally well developed in most hydrocarbon and geothermal reservoirs, which can produce complex fracture networks due to the activation of fractures during hydraulic stimulation. The present paper is devoted to developing a method
Changdong Ding, Yang Zhang, Qi Teng, Dawei Hu, Hui Zhou, Jianfu Shao, Chuanqing Zhang   +6 more
doaj   +1 more source

Fracture Permeability Enhancement During Fluid Injection Modulated by Pressurization Rate and Surface Asperities

Geophysical Research Letters, 2023
We present a series of controlled fluid injection experiments in the laboratory on a pre‐stressed natural rough fracture with a high initial permeability (∼10−13 m2) in granite using different fluid pressurization rates.
Yinlin Ji, Wei Zhang, Hannes Hofmann, Frédéric Cappa, Supeng Zhang   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Powder injection moulding at Canada’s National Research Council

, 2008
The National Research Council is Canada's leading industrial R&D organisation and its Industrial Materials Institute, based in Boucherville, Québec, is a key centre in the ongoing development of powder injection moulding technology.
Powder Injection Moulding International Magazine
core   +1 more source

Earthquake Iso‐Nuisance and Iso‐Damage Mapping for Alberta: Applications for Choosing Magnitude Thresholds to Manage Induced Seismicity

Earth's Future
We generate earthquake iso‐nuisance and iso‐damage maps for Alberta. These maps show the spatial distribution of earthquake magnitude required to reach a specific level of nuisance and damage, considering human exposure and surficial geological ...
Mauricio Reyes Canales, Elwyn Galloway, Steven Pawley, Javad Yusifbayov, Greg Hartman   +4 more
doaj   +1 more source

Collaborative optimization design method for water injection layer division and injection-production fluid allocation in high water cut reservoirs

Youqi dizhi yu caishoulu
Fine layered water injection is a crucial method to enhance oil recovery in high water cut reservoirs. However， the design of water injection layer division and injection-production fluid allocation often lacks coordination， limiting the full realization
ZHANG Xianmin, LI Shanshan, FENG Qihong, LIU Chen, LIU Xiangbin   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source