Results 51 to 60 of about 528,937 (346)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Mechanics of couple-stress fluid coatings [PDF]
, 1982 The formal development of a theory of viscoelastic surface fluids with bending resistance - their kinematics, dynamics, and rheology are discussed. It is relevant to the mechanics of fluid drops and jets coated by a thin layer of immiscible fluid with ...
Waxman, A. M.
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Wind Turbine Enhancement via Active Flow Control Implementation
Applied SciencesThe present research enhances the efficiency of an airfoil section from the DTU-10MW Horizontal Axis Wind Turbine (HAWT) via Active Flow Control (AFC) implementation and when using synthetic jets (SJ).
Marc Lahoz +3 more
doaj +1 more source
Experimental investigation of flow-induced sound of kite lines
Acta Acustica, 2023 In times of increasing importance of renewable energies, airborne wind energy (AWE) systems represent an emerging extension to conventional wind turbines.
Saur Lukas +3 more
doaj +1 more source
Parabolic equations on uniformly regular Riemannian manifolds and degenerate initial boundary value problems [PDF]
, 2014 In this work there is established an optimal existence and regularity theory for second order linear parabolic differential equations on a large class of noncompact Riemannian manifolds.
Amann, Herbert
core
Fuzzy Fluid Mechanics in Three Dimensions
, 2007 We introduce a rotation invariant short distance cut-off in the theory of an ideal fluid in three space dimensions, by requiring momenta to take values in a sphere. This leads to an algebra of functions in position space is non-commutative.
Arnold V. I. +4 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Drivers of physical connectivity between coral reefs along the Southeast African coastline
Scientific ReportsThe resilience and persistence of coral reef metapopulations strongly depend on their dispersal potential. Larval dispersal influences the diversity and genetic structure of coral populations and contributes to population recovery following disturbances.
Vibhav Atish Deoraj +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source