Results 51 to 60 of about 2,155,044 (206)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanics of inhomogeneous turbulence and interfacial layers [PDF]

, 2006
The mechanics of inhomogeneous turbulence in and adjacent to interfacial layers bounding turbulent and non-turbulent regions are analysed. Different mechanisms are identified according to the straining by the turbulent eddies in relation to the strength ...
Hunt, J.C.R., Eames, I., Westerweel, J. (author), Westerweel, J., Eames, I. (author), Hunt, J.C.R. (author)   +5 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Interactions and pattern formation in a macroscopic magnetocapillary SALR system of mermaid cereal

Nature Communications
When particles are deposited at a fluid interface they tend to aggregate by capillary attraction to minimize the overall potential energy of the system.
Alireza Hooshanginejad, Jack-William Barotta, Victoria Spradlin, Giuseppe Pucci, Robert Hunt, Daniel M. Harris   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Influence of the grain size and the fluid viscosity on the collapse of submerged sand columns

, 2022
Granular flows are ubiquitous in natural phenomena and are also used in various industrial applications. Nonetheless, they exhibit counter-intuitive behaviour as well as complex rheological behaviour, making them challenging to fully understand and model.
14th European Fluid Mechanics Conference, Papalexandris, Miltiadis, Riffard, Anouk   +2 more
core  

Preface: Latest advances in SPH for fluid mechanics

, 2023
Preface of SPH special issue in European Journal of Mechanics B ...
Khayyer A, Durante D, Violeau D, Shao S
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Microconfined High-Pressure Transcritical Channel Flow Database: Laminar, Transitional & Turbulent Regimes

Scientific Data
The potential of comprehending and managing microscale flows to enhance energy processes, especially in heat transfer and propulsion applications, remains largely untapped particularly for supercritical fluids, which have gained increased interest over ...
Ahmed Abdellatif, Carlos Monteiro, Marc Bernades, Lluís Jofre   +3 more
doaj   +1 more source