Results 1 to 10 of about 433,316 (304)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Complex & Intelligent SystemsHyper-redundant manipulator systems (HRMSs) have significant applications in various scenarios. Due to their excessive degrees of freedom (DOF), they can navigate into confined spaces and perform tasks such as exploration, detection, and maintenance ...
Hongcheng Ji +3 more
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Applied Sciences, 2018 In order to achieve high punching precision, good operational reliability and low manufacturing cost, the structural optimization of a high-speed press in the presence of a set of available alternatives comprises a heterogeneous multiple-attribute ...
Jin Cheng +4 more
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
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Multi-Objective Optimization of VBHF in Deep Drawing Based on the Improved QO-Jaya Algorithm
Chinese Journal of Mechanical EngineeringBlank holder force (BHF) is a crucial parameter in deep drawing, having close relation with the forming quality of sheet metal. However, there are different BHFs maintaining the best forming effect in different stages of deep drawing.
Xiangyu Jiang +3 more
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Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
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Scientific ReportsTo reduce the flow-induced noise of centrifugal pumps and reveal the noise source characteristics inside the pumps, this paper designs a bionic blade based on the “tubercle effect” of humpback whales.
Yongxin Jin +4 more
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FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
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Journal of Marine Science and EngineeringAccurate identification of hydrodynamic parameters is essential for high-fidelity modeling and control of unmanned underwater vehicles (UUVs). Compared with towing tank experiments and computational fluid dynamics simulations, system identification based
Xinyu Fei +7 more
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