Results 51 to 60 of about 628,248 (266)

Numerical simulation model of a reciprocating seal based on the mixed-lubrication theory

The Journal of Engineering, 2018
Based on the mixed-lubrication theory, a numerical simulation model of a reciprocating seal is established. The model includes finite element, fluid mechanics, contact mechanics and deformation mechanics analyses.
Chong Xiang, Zixi Wang, Xiaohong Jia, Fei Guo   +3 more
doaj   +1 more source

Numerical modeling of fluid flow in solid tumors. [PDF]

PLoS ONE, 2011
A mathematical model of interstitial fluid flow is developed, based on the application of the governing equations for fluid flow, i.e., the conservation laws for mass and momentum, to physiological systems containing solid tumors. The discretized form of
M Soltani, P Chen
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Reference values for intracranial pressure and lumbar cerebrospinal fluid pressure: a systematic review

Fluids and Barriers of the CNS, 2021
Background Although widely used in the evaluation of the diseased, normal intracranial pressure and lumbar cerebrospinal fluid pressure remain sparsely documented. Intracranial pressure is different from lumbar cerebrospinal fluid pressure.
Nicolas Hernandez Norager, Markus Harboe Olsen, Sarah Hornshoej Pedersen, Casper Schwartz Riedel, Marek Czosnyka, Marianne Juhler   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Pore structure evolution model of shale reservoir under different fluid pressures: a case study of Wufeng-Longmaxi Formation, SW China

Open Geosciences
Multiple studies had been conducted to improve the geological understanding and enrichment patterns of the Wufeng-Longmaxi Formation in the southeastern Sichuan Basin’s complex tectonic belt.
Sun Yue, Jiang Yuqiang, Jiang Chan, Yang Yixiao, Gu Yifan   +4 more
doaj   +1 more source

The Distribution Characteristics and Genesis Analysis of Overpressure in the Qiongzhusi Formation in the Zizhong Area, Sichuan Basin

Applied Sciences
Accurately predicting the genesis and distribution of reservoir pressure is essential for comprehending the distribution of oil and gas reservoirs while mitigating drilling risks.
Xuewen Shi, Yuran Yang, Qiuzi Wu, Yanyou Li, Yifan He, He Tian, Zhenxue Jiang, Zhongyu Bi, Huan Miao   +8 more
doaj   +1 more source