Results 61 to 70 of about 6,173 (250)

The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti, Vinicius Tassoni Civile, Talita Andrade Brandao, Felipe Ribeiro, Gisele Viana de Oliveira, Nathalia Sernizon Guimarães, Denise Steiner, Mahlatse Kgokolo   +7 more
wiley   +1 more source

Treatment of refractory diabetic macular edema with a fluocinolone acetonide implant in vitrectomized and non-vitrectomized eyes [PDF]

International Journal of Ophthalmology, 2018
AIM: To report real-life data on the use of an intravitreal fluocinolone acetonide implant in the treatment of refractory diabetic macular edema (DME) in pars plana vitrectomized (PPV) and non-PPV eyes.
Alberto La Mantia, Alan Hawrami, Heidi Laviers, Sudeshna Patra, Hadi Zambarakji   +4 more
doaj   +1 more source

Anti-Inflammatory Effect of Dexamethasone Controlled Released From Anterior Suprachoroidal Polyurethane Implants on Endotoxin-Induced Uveitis in Rats. [PDF]

, 2016
Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing
Ayres, E., Barbosa Saliba, J., Behar-Cohen, F., Bousquet, E., Fernandes-Cunha, G.M., Kowalczuk, L., Ligório Fialho, S., Naud, M.C., Oréfice, R.L., Rodrigues Da Silva, G., Silva-Cunha, A., Tekaya, M., Vieira, L., Zhao, M.   +13 more
core   +2 more sources

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, Volume 3, Issue 4, December 2025.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Retinal pigment epithelial cells can be cultured on fluocinolone acetonide treated nanofibrous scaffold

Materials & Design, 2023
Engineered tissue currently lacks requisite capacity to sustain cell viability and functionality. Here we demonstrate that human RPE cell lines (ARPE-19) can be cultured on ultrathin suspended electrospun nanofibre scaffolds (ENS) composed of hydrophobic
Biola F. Egbowon, Enzo Fornari, Joseph M. Pally, Alan J. Hargreaves, Bob Stevens, T. Martin McGinnity, Barbara K. Pierscionek   +6 more
doaj   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, Volume 3, Issue 4, November 2025.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

Fluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema

Drug Design, Development and Therapy, 2013
Wyatt B Messenger, Robert M Beardsle, Christina J FlaxelCasey Eye Institute, Oregon Health and Science University, Portland, OR, USAAbstract: Diabetic macular edema (DME) remains one of the leading causes of moderate to severe vision loss. Although laser
Messenger WB, Beardsley RM, Flaxel CJ
doaj  

Evaluating the Safety, Efficacy and Patient Acceptability of Intravitreal Fluocinolone Acetonide (0.2mcg/Day) Implant in the Treatment of Non-Infectious Uveitis Affecting the Posterior Segment

Clinical Ophthalmology, 2021
Laura R Steeples,1,2 Sasa Pockar,1 Nicholas P Jones,1,2 Inês Leal3,4 1Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; 2Faculty of Biology, Medicine &
Steeples LR, Pockar S, Jones NP, Leal I
doaj  

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 10, Page 742-753, October 2025.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Drug Delivery Implants in the Treatment of Vitreous Inflammation

Mediators of Inflammation, 2013
The eye is a model organ for the local delivery of therapeutics. This proves beneficial when treating vitreous inflammation and other ophthalmic pathologies.
Jillian Wang, Angela Jiang, Malav Joshi, John Christoforidis   +3 more
doaj   +1 more source