Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina +5 more
wiley +1 more source
Protocol for ultrafast immunolabeling and 3D imaging of whole organs and large tissues. [PDF]
Ding Z, Liu H, Chen J, Kusumbe AP.
europepmc +1 more source
Task‐Oriented Path Planning Towards Autonomous Sensor Network Deployment in Rainforest Canopies
An informative path planner for drone‐based deployment of wireless sensor networks in rainforest canopies is presented, addressing key challenges in large‐scale biodiversity monitoring. By integrating canopy surface detection with connectivity‐aware sampling under strict flight constraints, the approach enables efficient and reliable aerial sensor ...
Rita Santos Raminhos, Salua Hamaza
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Upadacitinib enhances platelet procoagulant responses in a subset of healthy individuals and patients with SLE: a pilot study. [PDF]
Tsegai V +9 more
europepmc +1 more source
Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints
This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito +5 more
wiley +1 more source
Phospholipase D2 acts upstream of PI4P 5-kinases in the response of neurons to extracellular viscosity. [PDF]
Kundu T, Püschel AW.
europepmc +1 more source
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source
Engineering migrasome-inspired extracellular vesicles through temperature stimuli on thermoresponsive substrate for retraction fiber formation and hypoosmotic vesiculation. [PDF]
Yoshikawa K, Saito S, Okochi M.
europepmc +1 more source
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang +20 more
wiley +1 more source
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source

