Results 141 to 150 of about 35,154 (267)

Inhibitors Targeting SARS‐CoV‐2 Papain‐Like Protease: Screening, Design, Synthesis, and Biological Evaluation

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga, Nilu Gone, Mariana Ortiz de Godoy, Gabriel Correa Verissimo, Giovanna de Jesus Agostinetto, Liam Urich, Nadine Krüger, Thales Kronenberger, Rafael Victorio Carvalho Guido, Anthony J. O’Donoghue, Stefan A. Laufer, Thanigaimalai Pillaiyar   +11 more
wiley   +1 more source

Development of an in-situ pressurised fluid extraction method for the extraction of PAHs prior to GC-MS analysis [PDF]

, 2008
Polycyclic aromatic hydrocarbons (PAHs) are derived from a number of sources including anthropogenic (i.e. industrial processes and combustion of fossil fuels) or natural (i.e. forest fires, volcanic activity and geological sources).
Cave, Mark, Dean, John, Lorenzi, Damien
core  

Two‐Stage, Sequential Aryne Carboiodanation Enabled by Mesomeric Priming

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
Two‐stage, sequential insertion of arynes into the carbon–iodine(III) bond of benziodoxole (BX) compounds is achieved by judicious choice of the BX/aryne pair in the first step, generating a mesomerically activated aryl‐BX primed for a second, discrete aryne insertion. This metal‐free strategy enables programed access to biaryl‐BXs and modular entry to
Shunya Morohashi, Jun Kikuchi, Eunsang Kwon, Naohiko Yoshikai   +3 more
wiley   +1 more source

Design, Synthesis, and Structural Analysis of Binaphthyl‐Based Chiral Benzindenes

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
This work explores the synthetic endeavors in constructing the first‐of‐a‐kind axially chiral benz[f]indenes as potential chiral ligands. The overall synthetic pathway spans across 9 steps with 15.9% overall yield. Challenges in constructing modified analogs as well as metal complexes are discussed. Chiral benzindenes are an unexplored structural motif
Marko Gobin, Nikola Topolovčan
wiley   +1 more source

A Cathodic Hydrogen Atom Transfer Strategy for Electrochemical Carboxylation of Dibenzylic C(sp3)H Bonds With CO2

ChemElectroChem, Volume 13, Issue 9, 5 May 2026.
A cathodically generated hydrogen atom transfer (HAT) strategy for the electrochemical carboxylation of dibenzylic C(sp3)H bonds with CO2 is developed. This strategy enables all key steps to occur at the same cathode, allowing efficient carboxylation under mild conditions.
Yuto Maeji, Toshimichi Kobayashi, Kento Kosugi, Yutaka Saga, Masanari Hirahara, Mio Kondo, Tetsuya Kambe, Shigeyuki Masaoka   +7 more
wiley   +1 more source

Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer, Jan Mathis Hornbostel, Richard Prediger, Sebastian Kluck, Michael Daub, Cornelia Lee‐Thedieck, Frederik Kotz‐Helmer   +6 more
wiley   +1 more source

Hydrocarbons identified in extracts from estuarine water accommodated no. 2 fuel oil by gas chromatography-mass spectrometry [PDF]

Results are presented on a computerized gas chromatograph-mass spectrometer analysis of methylene chloride and n-heptane extracts of a No. 2 fuel oil accommodated estuarine water sample.
Bieri, R. H., Lewis, B. W., Walker, A. L.   +2 more
core   +1 more source

Hybrid Liquid Metal Cathode Enables High‐Performance Intrinsically Stretchable OLEDs

Advanced Materials, Volume 38, Issue 25, 4 May 2026.
We report a hybrid liquid metal (Hyb‐LM) cathode engineered via selective rupture of liquid metal particles (LMPs), forming a bilayer architecture with a surface liquid metal (LM) layer and underlying LMP layer, which has benefits of both LM and LMPs.
Wonbeom Lee, Wei Liu, Cheng Zhang, Seungmin Shin, Jaejun Lee, Jaedong Jang, Sanggil Park, Seungbum Hong, Sihong Wang, Himchan Cho   +9 more
wiley   +1 more source

One‐Dimensional Polycyclic Aromatic Hydrocarbons Incorporating Multiple Dithiafulvene Units—Novel Multi‐Redox and Electrochromic Systems

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
Planar polycyclic aromatic hydrocarbons (PAHs) incorporating three or four dithiafulvene (DTF) units were synthesized via Horner–Wadsworth–Emmons reactions to create large π‐conjugated redox‐active frameworks. These molecules display strong intermolecular associations and distinct odd–even redox behavior, enabling formation of mixed‐valence and radical‐
Cecilie Rindom, Florim Seljmani, Lukas Bradley Woodcock, Mogens Brøndsted Nielsen   +3 more
wiley   +2 more sources

Fluorometric Detection of Sarin Vapor Using Fluorene and Fluorenone Derivatives

Analysis &Sensing, Volume 6, Issue 3, May 2026.
In this study, we present the detection of the actual nerve agent sarin in the gas phase, assessing more than twenty fluorene and fluorenone derivatives as organic fluorescent probes. One molecule in particular showed very promising results in terms of stability and selectivity.
Valentin A. Bureau, Sébastien Penlou, Sonia Sousa Nobre, Alexandre Carella, Jean‐Pierre Simonato   +4 more
wiley   +1 more source