Results 101 to 110 of about 496,070 (334)
New synthetic strategies for xanthene-dye-appended cyclodextrins
Beilstein Journal of Organic Chemistry, 2016 Xanthene dyes can be appended to cyclodextrins via an ester or amide bridge in order to switch the fluorescence on or off. This is made possible through the formation of nonfluorescent lactones or lactams as the fluorophore can reversibly cyclize.
Milo Malanga +5 more
doaj +1 more source
Biochemical Pharmacology, 2015 Organic Anion Transporting Polypeptides (OATPs), encoded by genes of the Solute Carrier Organic Anion (SLCO) family, are transmembrane proteins involved in the uptake of various compounds of endogenous or exogenous origin.
Izabel Patik +8 more
semanticscholar +1 more source
Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues
Advanced Healthcare Materials, EarlyView.Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman +7 more
wiley +1 more source
Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies
Advanced Healthcare Materials, EarlyView.Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best +5 more
wiley +1 more source
Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery
Acta Neurochirurgica, 2015 Dear Editor, Five-aminolevulinic acid (5-ALA)-derived fluorescence is approved for fluorescence-guided resections of malignant gliomas, relying on selective synthesis and accumulation of protoporphyrin IX (PPIX) within malignant glioma cells [5 ...
M. Schwake +3 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, EarlyView.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu +10 more
wiley +1 more source
Preparation and Characterization of Intrinsically Fluorescent Polyphosphazene Microspheres
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 The novel polyphosphazene and cyclomatrix type microspheres were synthesized via a one-pot self-assembly polycondensation method. Octachlorocyclotetraphosphazene and two fluorescent compounds; fluorescein and curcumin were used as a crosslinker and ...
Simge Metinoğlu Örüm
doaj
Comparison of the crack pattern in accelerated corrosion tests and in finite elements simulations [PDF]
, 2010 In this work, the crack pattern obtained in accelerated corrosion tests is compared to the one obtained in numerical simulations for reinforced steel concrete samples.
Planas Rosselló, Jaime +2 more
core +1 more source