Results 301 to 310 of about 328,500 (372)

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection. [PDF]

J Ophthalmic Inflamm Infect
Song W, Au A, Sarraf D, Prasad P, Tsui E.   +4 more
europepmc   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway. [PDF]

Invest Ophthalmol Vis Sci
Wang Y, Xu Z, Wei L, Lu Y, Shi Y, Wen S, Lv X, Huang K, Lu F, Qu J, Hu L.   +10 more
europepmc   +1 more source

Author Correction: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α. [PDF]

Sci Rep
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J.   +17 more
europepmc   +1 more source

Successful Natalizumab Treatment of Two Female Individuals With Susac Syndrome. [PDF]

Eur J Neurol
Konitsioti AM, Grajewski R, Schlamann M, Schroeter M, Fink GR, Warnke C.   +5 more
europepmc   +1 more source

A Rare Vitreoretinal Degenerative Disorder: Goldmann-Favre Syndrome Complicated with Choroidal Neovascularization in a Pediatric Patient. [PDF]

Diagnostics (Basel)
Szala K, Wójcik-Niklewska B.
europepmc   +1 more source

Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy. [PDF]

Sci Rep
Ramani RS, Tan I, Bussau L, O'Reilly LA, Silke J, Angel C, Celentano A, Whitehead L, McCullough M, Yap T.   +9 more
europepmc   +1 more source

A Systematic Review of Advances in AI-Assisted Analysis of Fundus Fluorescein Angiography (FFA) Images: From Detection to Report Generation. [PDF]

Ophthalmol Ther
Yu T, Shao A, Wu H, Su Z, Shen W, Zhou J, Lin X, Shi D, Grzybowski A, Wu J, Jin K.   +10 more
europepmc   +1 more source