Results 151 to 160 of about 2,689 (213)

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Enhanced Separation of Extracellular Vesicles Using Capillary Isotachophoresis With Spacer Compounds. [PDF]

Electrophoresis
de Putter MPP, Capuano A, Numan M, Hankemeier T, Shakalisava Y.   +4 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Proteolysis Assays With Conserved or Aminofluorescein-Labeled Red Blood Cells. [PDF]

Biomed Res Int
Al-Essa MK, Al-Qudah T, Al Hadidi AKA, Alshubbak NH.   +3 more
europepmc   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

Advanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang, Zhenqi Jiang, Wenjia Zhang, Juncheng Wu, Haozhuo Guo, Changlei Li, Mingwei Sun, Xiaoying Tang, Yue Zhang, Wei Huang, Huadan Xue, Yang Du   +11 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Visualization of bone formation in sheep's middle ear by using fluorochrome sequential labelling (FSL). [PDF]

Sci Rep
Kemper M, Kluge A, Ney M, Beleites T, Zeidler-Rentzsch I, Keil C, Zahnert T, Neudert M.   +7 more
europepmc   +1 more source

Evaluation of survivorship and annulus validation in calcein-stained freshwater unionid mussels. [PDF]

Sci Rep
Eismont AL, deMoulpied M, Robertson CR, Lopez RR, Randklev CR.   +4 more
europepmc   +1 more source

Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals. [PDF]

Sci Rep
Niimi T, Miyazaki N, Oiki H, Uemura M, Zeng S, Promsut W, Ota N, Nonaka S, Takei H, Nittono H, Narushima S, Yanagida A, Hiramatsu R, Kanai-Azuma M, Takami S, Fujishiro J, Kanai Y.   +16 more
europepmc   +1 more source

Optimized laboratory techniques for assessing the quality of pre-stripped DMEK grafts. [PDF]

Sci Rep
Sagnial T, Ninotta S, Goin P, Aouimeur I, Parveau L, Poinard S, Dorado Cortez O, Ben Moussa O, Vaitinadapoule H, Gauthier AS, Gain P, Thuret G, He Z.   +12 more
europepmc   +1 more source