Results 51 to 60 of about 14,112 (297)
Fluorescent Probes for Analysis and Imaging of Monoamine Oxidase Activity [PDF]
Monoamine oxidases catalyze the oxidative deamination of dietary amines and amine neurotransmitters, and assist in maintaining the homeostasis of the amine neurotransmitters in the brain.
Ahn, KH, Jun, YW, Kim, D
core +1 more source
DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol [PDF]
2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models.
CAPPELLO, Francesco+10 more
core +2 more sources
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan+4 more
wiley +1 more source
Transient Stiffness Patterning in Hydrogels Driven by Dissipative Mechanochemical Coupling
Force‐induced disulfide bond rupture in a polymer‐based hydrogel, coupled with chemical or electrochemical reoxidation, leads to the transient modulation of the hydrogel's stiffness properties. High spatiotemporal control is achieved by this dissipative process, enabling the development of out‐of‐equilibrium stiffness patterns and transient, dose ...
Roberto Baretta+2 more
wiley +1 more source
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song+8 more
wiley +1 more source
High-Throughput Analysis With 96-Capillary Array Electrophoresis and Integrated Sample Preparation for DNA Sequencing Based on Laser Induced Fluorescence Detection [PDF]
The purpose of this research was to improve the fluorescence detection for the multiplexed capillary array electrophoresis, extend its use beyond the genomic analysis, and to develop an integrated micro-sample preparation system for high-throughput DNA ...
Xue, Gang
core +1 more source
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen+5 more
wiley +1 more source
Rotating Liquid Marble Microreactors for Enhanced Enzymatic Reactions
Dynamic magnetic liquid marbles (LMs), stabilized by hydrophobic magnetic proteinaceous colloidosomes, function as effective microreactors for enzymatic processes. Precise magnetic manipulation allows for the rotation of these LMs, enhancing the efficiency of the enzymatic cascade reaction both at the air/water interface and within biphasic enzyme ...
Weijie Jiang+5 more
wiley +1 more source
A bacterial cysteine protease effector protein interferes with photosynthesis to suppress plant innate immune responses [PDF]
The bacterial pathogen Pseudomonas syringae pv tomato DC3000 suppresses plant innate immunity with effector proteins injected by a type III secretion system (T3SS).
Abbink+60 more
core +2 more sources
In this study, a physically enhanced vascular dECM bioink and used 3D‐coaxial bioprinting are developed to fabricate mature brain blood vessels for cerebral atherosclerosis research. This model demonstrates that vascular geometry‐induced hemodynamic changes trigger vascular inflammation, ensuring its potential for cerebrovascular research.
Wonbin Park+7 more
wiley +1 more source