Results 231 to 240 of about 1,649,089 (269)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Torsion-induced π-conjugation Offers an Approach to Small Coumarin-based Color-changing Fluorescent Sensors of Esterase Activity. [PDF]

Chemistry
Oronova A, Bobnock G, Begoyan VV, Tanasova M.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

MAcro Plant Projection Imaging (MAPPI): An open, scalable platform for whole-plant fluorescence real-time imaging. [PDF]

Sci Adv
Tortora G, Orlando Marchesano BM, Buratti S, Luoni L, Grenzi M, Yoshioka K, Contartese V, Candeo A, Costa A, Bassi A.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Characterization of the biodistribution profile of a human Dialyzable Leukocyte Extract (hDLE) by <i>in vivo</i> fluorescence imaging: a strategy to infer the ADME profile of complex multipeptide drugs. [PDF]

Front Pharmacol
Fragozo A, Trejo-Martínez I, Domínguez-Bernal K, Valencia-Flores L, Macias-Palacios Z, Pavón L, Pérez-Torres A, Aguilar-Alonso FA, Vázquez-Leyva S, Vallejo-Castillo L, Pérez-Tapia SM.   +10 more
europepmc   +1 more source

In vivo detection of retained gadolinium in bone by x-ray fluorescence

, 2019
Lord, Michelle
openalex   +1 more source

Bottom-up microwave transformation of molecules to carbon dots for detection and encryption applications. [PDF]

RSC Adv
Annamalai A, Elumalai S, Sangaraju S, Hassan FM.   +3 more
europepmc   +1 more source

Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters. [PDF]

Nanoscale Adv
Yadavalli HC, Nagda R, Kang J, Cho M, Lou C, Yang SW, Thulstrup PW, Bjerrum MJ, Shah P.   +8 more
europepmc   +1 more source