Results 281 to 290 of about 3,329,276 (417)
Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior
Human pluripotent stem cells (hPSCs) with TP53‐depleting mutations are generated, mimicking commonly occurring events in vitro. Loss of TP53 does not alter pluripotency status or in vitro differentiation potential but causes genetic instability and transcriptome changes and confers superior clonal and anchorage‐free growth and higher chemotherapeutic ...
Joaquin Montilla‐Rojo+9 more
wiley +1 more source
A direct experimental test of Ohno's hypothesis. [PDF]
Mihajlovic L+7 more
europepmc +1 more source
Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter+3 more
wiley +1 more source
Neural Networks for Quantifying Laboratory Confocal Micro X-ray Fluorescence Measurements. [PDF]
Förste F+6 more
europepmc +1 more source
Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Impacts of sequence and structure on pyrrolocytosine fluorescence in RNA. [PDF]
Coulson TL, Widom JR.
europepmc +1 more source
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang+6 more
wiley +1 more source
Fluorometric combination analysis of conformational changes in urea-induced unfolding of soybean protein isolates and their complexes with casein. [PDF]
Gao Y+8 more
europepmc +1 more source