Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy
Advanced Functional Materials, EarlyView.MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee +6 more
wiley +1 more source
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. [PDF]
Nat Commun, 2018 Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identified
Menchon G +10 more
europepmc +2 more sources
Scientific ReportsWe present a comprehensive spectroscopic study supported by theoretical quantum chemical calculations conducted on a molecular system (4-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (C1) and the antibiotic Amphotericin B (AmB)) that exhibits highly ...
Lidia Ślusarczyk +11 more
doaj +1 more source
Research on the transition dynamics and linear (nonlinear) optical properties of mCherry [PDF]
arXiv, 2023 In this study, we explore the electron transition mechanism and optical properties of the popular red fluorescent protein mCherry. By examining the charge transfer spectrum and combining it with the mCherry hole-electron distribution, we identify that the charge transfer between the phenolate and imidazolinone loops significantly contributes to the ...
arxiv
The aggregation of cytochrome C may be linked to its flexibility during refolding [PDF]
, 2016 Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with denaturant, a ...
A Basu +19 more
core +1 more source
Multi‐Scaled Cellulosic Nanonetworks from Tunicates
Advanced Functional Materials, EarlyView.Microbial and plant nanonetworks of cellulose have enabled a wide range of high‐performance yet sustainable materials. Herein, a third class of cellulosic nanonetworks is showcased by exploiting the only animal tissue‐producing cellulose nanofibers, i.e., ascidians. An ultrastructure including spherical cells and a microvasculature with diameters of 50–
Mano Govindharaj +10 more
wiley +1 more source
Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis [PDF]
, 2015 Funding This work was supported by a Wellcome Trust Programme grant [092552/A/10/Z awarded to I.R.B., S.M., J. H. Naismith (University of St Andrews, St Andrews, U.K.), and S. J. Conway (University of Oxford, Oxford, U.K.)] (T.R.
Akiko Rasmussen +12 more
core +4 more sources
Designing of Self‐Dispersing Soft Dendritic Microcleaners for Microplastics Capture and Recovery
Advanced Functional Materials, EarlyView.The capture and recovery of microplastics from open aquatic systems is a complex problem, which necessitates nontrivial solutions. The principles of a comprehensive multistage process based on sustainably sourced microcleaners with hierarchical morphology are demonstrated.
Haeleen Hong +3 more
wiley +1 more source
Evidence of Protein Adsorption in Pegylated Liposomes: Influence of Liposomal Decoration
Nanomaterials, 2017 In order to contribute to a better knowledge of the events involved in the formation of the protein corona when nanoparticles (NPs) come in contact with proteins, we report a study about the changes on the physicochemical properties of pristine ...
Marc Sangrà +4 more
doaj +1 more source
Torsion and bending of nucleic acids studied by subnanosecond time-resolved fluorescence depolarization of intercalated dyes [PDF]
, 1982 Subnanosecond time‐resolved fluorescence depolarization has been used to monitor the reorientation of ethidium bromide intercalated in native DNA, synthetic polynucleotide complexes, and in supercoiled plasmid DNA.
Millar, D. P. +2 more
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