Results 61 to 70 of about 276,058 (259)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Advances of super-resolution fluorescence polarization microscopy and its applications in life sciences

open access: yesComputational and Structural Biotechnology Journal, 2020
Fluorescence polarization microscopy (FPM) analyzes both intensity and orientation of fluorescence dipole, and reflects the structural specificity of target molecules. It has become an important tool for studying protein organization, orientational order,
Long Chen   +6 more
doaj  

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

open access: yeseLife, 2017
The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when
Xuemeng Zhang   +5 more
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

High efficiency entangled photon pair collection in type II parametric fluorescence [PDF]

open access: yes, 2001
We report on a method for optimizing the collection of entangled photon pairs in type-II parametric fluorescence. With this technique, we detected 360000 polarization-entangled photon pairs per second in the near-IR region in single-mode optical fibers.
arxiv   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Pengukuran Perubahan Sudut Polarisasi oleh Fluoresensi pada Sampel Minyak Zaitun [PDF]

open access: yes, 2016
The aim of this research is to show how the quality difference of cooking oil affect polarization angle changes of fluorescence. The fluorescence could be usefull to identify quality of matter according to colour changes.
Firdausi, K. S. (Ketut)   +1 more
core  

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

open access: yesAdvanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang   +6 more
wiley   +1 more source

A New Application of Spin and Fluorescence Double-Sensor Molecules

open access: yesMolecules, 2023
EPR imaging techniques are known to be successful tools for mapping living bodies, especially because of the high transparency of tissues in the microwave range.
Flórián Bencze   +5 more
doaj   +1 more source

Resonance fluorescence from an asymmetric quantum dot dressed by a bichromatic electromagnetic field [PDF]

open access: yesPhys. Rev. A 95, 013834 (2017), 2016
We present the theory of resonance fluorescence from an asymmetric quantum dot driven by a two-component electromagnetic field with two different frequencies, polarizations and amplitudes (bichromatic field) in the regime of strong light-matter coupling.
arxiv   +1 more source

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