Results 281 to 290 of about 416,920 (380)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

A non-fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers. [PDF]

FEBS Open Bio
Shojaei S, Barzegar Behrooz A, Cordani M, Aghaei M, Azarpira N, Klionsky DJ, Ghavami S.   +6 more
europepmc   +1 more source

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

Advanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski, Svenja Nellinger, Franziska Brigitte Albrecht, Petra Juliane Kluger   +3 more
wiley   +1 more source

Agents for Fluorescence-Guided Glioblastoma Surgery. [PDF]

Pharmaceutics
Romeo E, Tzakos AG, Crook T, Syed N, Voulgaris S, Alexiou GA.   +5 more
europepmc   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source

Overview of detection methods of fetomaternal haemorrhage. [PDF]

Front Physiol
Li X, Li C, Liu T.
europepmc   +1 more source

Peptide Display Directed Assembly of Biopolymer Core–Silica Shell Particles

Advanced Healthcare Materials, EarlyView.
Bacterial cells are engineered to produce biopolyester particles displaying peptides mediating growth of silica. Peptide‐coated biopolyester particles are treated with silica precursors and silica shell formation is studied. Transmission electron microscopy shows silica‐coated BPs which are formed after the silicification treatment. Characterization of
Deeptee Chandrashekhar Pande, Frank Sainsbury, Bernd H. A. Rehm   +2 more
wiley   +1 more source

A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes. [PDF]

EBioMedicine
Jin S, Li C, Jia X, Quan J, Guo X, Kong W, Wang Y, Wang Y, Tian J, Hu Z, Tang J.   +10 more
europepmc   +1 more source