Results 41 to 50 of about 10,967 (253)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Seasonal dynamics of dissolved organic matter in a small tropical estuary-coastal bay continuum: distribution, transformation, flux, and global perspectives

Frontiers in Marine Science
The export and transformation of riverine dissolved organic matter (DOM) at the river-sea interface are critical to understanding carbon budgets in tropical regions, yet remain underexplored in small watersheds.
Pengfei Liu, Kuan Jiang, Qi Tan, Fajin Chen, Renming Jia, Chao Wang, Chao Wang, Chao Wang, Chao Wang   +8 more
doaj   +1 more source

Aerosol inputs affect the optical signatures of dissolved organic matter in NW Mediterranean coastal waters

Scientia Marina, 2016
Aeolian inputs of organic and inorganic nutrients to the ocean are important as they can enhance biological production in surface waters, especially in oligotrophic areas like the Mediterranean.
E. Denisse Sánchez-Pérez, Isabel Marín, Sdena Nunes, Fran L. Aparicio, Laura Fernández-González, Francesc Peters, Mireille Pujo-Pay, Pascal Conan, Cèlia Marrasé   +8 more
doaj   +1 more source

Source, distribution, and transformation of dissolved and particulate organic matters in Qinzhou Bay, Northern Beibu Gulf

Frontiers in Marine Science, 2023
Both dissolved and particulate organic matters (DOM and POM) provide a reduced carbon pool of considerable size in coastal ecosystems, and the two are closely linked.
Shangjun Cai, Chao Wang, Chao Wang, Chao Wang, Chao Wang, Qingmei Zhu, Qingmei Zhu, Qingmei Zhu, Qibin Lao   +8 more
doaj   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, EarlyView.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Photodegradation of fluorescent dissolved organic matter in river waters

GEOCHEMICAL JOURNAL, 2007
Photodegradation of dissolved organic matter (DOM), collected from two upstream and one downstream sites in the Lake Biwa watershed in Japan, was investigated using fluorescence properties of three-dimensional excitation emission matrix (3-D EEM).
MOSTOFA, KHAN M. G., YOSHIOKA, TAKAHITO, KONOHIRA, EIICHI, TANOUE, EIICHIRO   +3 more
openaire   +2 more sources

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, EarlyView.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

Remote sensing monitoring of fluorescent dissolved organic matter in Admiralty Bay: fusion of multi-source signal removal and machine learning

Science of Remote Sensing
Fluorescent dissolved organic matter (fDOM), a fluorescent component of dissolved organic matter (DOM), plays a crucial role in tracing pollution pathways in marine environments.
Ruiwu Zhang, Ruru Deng, Jun Ying, Jiayi Li, Yu Guo, Junying Yang, Cong Lei   +6 more
doaj   +1 more source