Results 91 to 100 of about 789,313 (250)

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source

Recent Progress on Gold-Nanocluster-Based Fluorescent Probe for Environmental Analysis and Biological Sensing

Journal of Analytical Methods in Chemistry, 2019
Gold nanoclusters (AuNCs) are one of metal nanoclusters, which play a pivotal role in the recent advances in the research of fluorescent probes for their fluorescence effect.
Mingxian Liu, Fenglin Tang, Zhengli Yang, Jing Xu, Xiupei Yang   +4 more
doaj   +1 more source

Quantification of Two Fluorophores’ Concentration Ratio in a Mice Model in Preparation for a Proposed Method for Early Detection of Alzheimer’s Disease

Applied Sciences, 2018
Many biomedical applications require concentration measurements of biological compounds, which may be achieved using targeted fluorescent probes. It has been shown that the ratio between amyloid-Beta and tau protein in the cerebrospinal fluid (CSF) is a ...
Osnat Harbater, Margalit Efrati, Israel Gannot   +2 more
doaj   +1 more source

Smart fluorescent probes for imaging macrophage activity [PDF]

, 2016
Macrophages are multi-functional immune cells with key roles in host defense and tissue remodelling. The broad array of macrophage functions has prompted the development of very diverse smart fluorescent architectures, rationally designed to elicit a ...
Antonio Fernández, Marc Vendrell, Vendrell , Marc, Fernandez Vargas, Antonio   +3 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Recent advances in self‐immobilizing fluorescent probes for in vivo imaging

Smart Molecules
In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events and disease diagnosis.
Yong Zhang, Xuemei Lv, Yafu Wang, Xueqian Chen, Jinchao Zhang, Dongdong Su   +5 more
doaj   +1 more source

TUNING FLUORESCENT PROBES FOR BIOMEDICAL APPLICATIONS

, 2013
Fluorescent probes are important research tools for real-time imaging of live cells and a powerful tool for cell biologists. The primary goal of my research project is to develop novel fluorescent probes for facilitating biomedical research. During my Ph.
Yapici, Nazmiye Bihter
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source